Role of Nisoldipine on Blood Pressure, Cardiac Hypertrophy, and Atrial Natriuretic Peptides in Spontaneously Hypertensive Rats

The effect of long-term treatment with the calcium antagonist nisoldipine on development of hypertension, cardiac hypertrophy, and plasma levels of atrial natriuretic peptides (ANP) was determined in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) of the same age. Measurement of im...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1987-09, Vol.10 (3), p.303-307
Main Authors: STASCH, JOHANNES-PETER, KAZDA, STANISLAV, HIRTH, CLAUDIA, MORICH, FRANK
Format: Article
Language:English
Subjects:
Animals
Atrial Natriuretic Factor - blood
Blood Pressure - drug effects
Cardiomegaly - prevention & control
Hypertension - drug therapy
Hypertension - physiopathology
Male
Nifedipine - analogs & derivatives
Nifedipine - pharmacology
Nisoldipine
Rats
Rats, Inbred SHR
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Summary:The effect of long-term treatment with the calcium antagonist nisoldipine on development of hypertension, cardiac hypertrophy, and plasma levels of atrial natriuretic peptides (ANP) was determined in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) of the same age. Measurement of immunoreactive ANP in plasma provided a sensitive marker for the severity of hypertension and the associated cardiac overload. Long-term treatment with nisoldipine prevented the development of hypertension, the associated heart failure, and the increase of plasma levels of ANP in SHR but had no effect on systolic blood pressure, heart weight, and plasma levels of ANP in WKY. In addition, nisoldipine had a therapeutic effect in old SHR with manifest cardiac failure in end-stage hypertension, as evidenced not only by the reduction of blood pressure but also by the reduction of cardiac hypertrophy, of elevated immunoreactive ANP in plasma, and of increased plasma renin activity.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.10.3.303