Genetic mechanisms of early neurogenesis in Drosophila melanogaster

The neurogenic ectoderm of Drosophila melanogaster consists of the ventral neuroectoderm and the procephalic neuroectoderm. It is hypothesized that epidermal and central neural progenitor cells separate from each other in three steps: conference on the neuroectodermal cells the capability of produci...

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Bibliographic Details
Published in:Molecular neurobiology 1995-04, Vol.10 (2-3), p.75-89
Main Author: Campos-Ortega, J A
Format: Article
Language:English
Subjects:
Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation
Cell Lineage
Central Nervous System - embryology
DNA-Binding Proteins - genetics
DNA-Binding Proteins - physiology
Drosophila melanogaster
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila Proteins
Ectoderm - cytology
Ectoderm - metabolism
Gene Expression Regulation, Developmental
Genes, Insect
Hyperplasia
Intracellular Signaling Peptides and Proteins
Membrane Proteins - genetics
Membrane Proteins - physiology
Morphogenesis - genetics
Receptors, Notch
Sense Organs - embryology
Stem Cells - cytology
Stem Cells - metabolism
Transcription Factors - genetics
Transcription Factors - physiology
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Summary:The neurogenic ectoderm of Drosophila melanogaster consists of the ventral neuroectoderm and the procephalic neuroectoderm. It is hypothesized that epidermal and central neural progenitor cells separate from each other in three steps: conference on the neuroectodermal cells the capability of producing neural or epidermal progenies, separation of the two classes of progenitor cells, and specification of particular types of neuroblasts and epidermoblasts. Separation of neuroblasts and epidermoblasts is controlled by proneural and neurogenic genes. Delta and Notch serve as mediators of direct protein-protein interactions. E(SPL)-C inhibits neurogenesis, creating epidermal cells. The achaete-scute complex (AS-C) controls the commitment of nonoverlapping populations of neuroblasts and leads the development of neuroectodermal cells as neuroblasts.
ISSN:0893-7648
DOI:10.1007/BF02740668