In vivo induction of apoptosis by influenza virus

1 Department of Microbiology 2 Department of Pediatrics and 3 Department of Pathology, Fukui Medical School, Fukui 910-11, Japan Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragme...

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Bibliographic Details
Published in:Journal of general virology 1995-11, Vol.76 (11), p.2869-2873
Main Authors: Mori, Isamu, Komatsu, Takayuki, Takeuchi, Kenji, Nakakuki, Kazuya, Sudo, Masakatsu, Kimura, Yoshinobu
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bronchi - pathology
Chromatin - physiology
DNA Damage
Epithelium - pathology
Humans
influenza A virus
Influenza A virus - physiology
Influenza, Human - pathology
Influenza, Human - virology
Lung - pathology
Male
Mice
Mice, Inbred C3H
Thymus Gland - pathology
Time Factors
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Summary:1 Department of Microbiology 2 Department of Pediatrics and 3 Department of Pathology, Fukui Medical School, Fukui 910-11, Japan Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo . * Author for correspondence. Fax +81 776 61 8104. Received 15 May 1995; accepted 5 July 1995.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-76-11-2869