EFFECT OF SENEGIN-II ON BLOOD GLUCOSE IN NORMAL AND NIDDM MICE

The hypoglycemic effect of senegin-II, the main component of Polygala senega (Polygalaceae), was examined in normal and KK-Ay mice, one of the model animals of non-insulin-dependent diabetes mellitus (NIDDM). Senegin-II (2.5mg/kg) reduced the level of blood glucose in normal mice from 220±8 to 131±5...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1995/08/15, Vol.18(8), pp.1159-1161
Main Authors: KAKO, Mami, MIURA, Toshihiro, USAMI, Masaru, NISHIYAMA, Yumi, ICHIMARU, Momoyo, MORIYASU, Masataka, KATO, Atsushi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - drug effects
Diabetes Mellitus, Type 2 - blood
Disease Models, Animal
General pharmacology
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
hypoglycemic effect
Injections, Intraperitoneal
KK-Ay mice
Male
Medical sciences
Mice
normal mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Roots - chemistry
Polygaia senega
senegin-II
triterpenoid glycoside
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Summary:The hypoglycemic effect of senegin-II, the main component of Polygala senega (Polygalaceae), was examined in normal and KK-Ay mice, one of the model animals of non-insulin-dependent diabetes mellitus (NIDDM). Senegin-II (2.5mg/kg) reduced the level of blood glucose in normal mice from 220±8 to 131±5mg/dl 4 hours after intraperitoneal administrarion (P
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.18.1159