Microheterogeneity of acute phase proteins in patients with clinically active and clinically nonactive osteoarthritis

Microheterogeneity of two acute phase glycoproteins, alpha-1-acid glycoprotein (AGP) and alpha-1-antichymotrypsin (ACT), concentrations of AGP, ACT, and C-reactive protein (CRP), and levels of three cytokines: interleukin 1 beta (IL-1-beta), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF...

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Bibliographic Details
Published in:Clinical rheumatology 1995-07, Vol.14 (4), p.434-440
Main Authors: Hrycaj, P, Stratz, T, Kovac, C, Mennet, P, Müller, W
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
alpha 1-Antichymotrypsin - analysis
C-Reactive Protein - analysis
Cytokines - analysis
Female
Humans
Immunoelectrophoresis
Interleukin-1 - analysis
Interleukin-6 - analysis
Male
Middle Aged
Orosomucoid - analysis
Osteoarthritis - blood
Synovial Fluid - metabolism
Tumor Necrosis Factor-alpha - analysis
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Summary:Microheterogeneity of two acute phase glycoproteins, alpha-1-acid glycoprotein (AGP) and alpha-1-antichymotrypsin (ACT), concentrations of AGP, ACT, and C-reactive protein (CRP), and levels of three cytokines: interleukin 1 beta (IL-1-beta), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) were determined in 61 serum samples and 7 synovial fluids (SFs) obtained from patients (n = 61) with osteoarthritis. Using affinity immunoelectrophoresis with concanavalin A (conA), a significant decrease in the reactivity of AGP and ACT with this lectin was found in patients with clinically active osteoarthritis when compared to those with clinically nonactive disease (p < 0.001 and p < 0.05, respectively). There was no increase in the concentration of AGP, ACT, and C-reactive protein (CRP) in the sera examined. In particular, no increase in the serum level of these proteins was found in the patients with clinically active disease. Low concentrations of IL-6 and TNF-alpha were found in most sera and SFs examined. In 6 out of 7 SFs available, IL-6 concentrations were higher than in the respective serum samples but for TNF-alpha the same could be shown in one case only. Low concentrations of IL-1-beta were found in 4 serum samples obtained from patients with clinically active osteoarthritis and in no SF specimen studied. In the entire group, serum level of TNF-alpha correlated weakly with the AGP and ACT reactivity coefficients with conA (r = 0.3634, p < 0.005 and r = 0.3324, p < 0.02, respectively).
ISSN:0770-3198
1434-9949
DOI:10.1007/BF02207678