Humoral Immune Responses in Acute Schistosomiasis Mansoni: Relation to Morbidity

An analysis of 25 individuals simultaneously exposed to cercariae of Schistosoma mansoni showed that morbidity (measured by the clinical/sonographic index) was more severe in patients with high-level egg output, irrespective of age or intensity of water contact High levels of IgM and IgG antibodies...

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Bibliographic Details
Published in:Clinical infectious diseases 1995-09, Vol.21 (3), p.608-615
Main Authors: Rabello, Ana L. T., Garcia, Maria Monica A., da Silva, Rogério A. Pinto, Rocha, Roberto S., Chaves, Adelu, Katz, Naftale
Format: Article
Language:English
Subjects:
Acute Disease
Acute diseases
Adolescent
Adult
Animals
Antibodies
Antibodies, Helminth - blood
Antibody Specificity
Antigens
Biological and medical sciences
Brazil - epidemiology
Child
Clinical Articles
Correlations
Diseases caused by trematodes
Eggs
Feces - parasitology
Female
Helminthic diseases
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Immunoglobulin M - blood
Infections
Infectious diseases
Lymph Nodes - diagnostic imaging
Male
Medical sciences
Middle Aged
Morbidity
Parasitic diseases
Schistosoma mansoni
Schistosoma mansoni - immunology
Schistosomiases
Schistosomiasis
Schistosomiasis mansoni
Schistosomiasis mansoni - epidemiology
Schistosomiasis mansoni - etiology
Schistosomiasis mansoni - immunology
Symptoms
Ultrasonography
Water - parasitology
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Description
Summary:An analysis of 25 individuals simultaneously exposed to cercariae of Schistosoma mansoni showed that morbidity (measured by the clinical/sonographic index) was more severe in patients with high-level egg output, irrespective of age or intensity of water contact High levels of IgM and IgG antibodies to keyhole limpet hemocyanin and of IgA antibody to soluble egg antigen were documented predominantly during the acute phase of illness. Increased levels of these antibodies and of IgM antibody to soluble egg antigen correlated positively with morbidity after adjustment for age and intensity of water contact.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/21.3.608