The Role of Serology in the Diagnosis of Helicobacter pylori Infection in Children

The aim of this study was to evaluate the diagnostic accuracy of serologic tests and to verify whether specific IgG antibody can be used in the diagnosis of Helicobacter pylori infection in children without endoscopy. Serologic and endoscopic examinations were performed in 310 children (1 month-15 y...

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Bibliographic Details
Published in:Clinical pediatrics 1995-09, Vol.34 (9), p.458-462
Main Authors: Sim, J G, Kim, E C, Seo, J K
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Amoxicillin - therapeutic use
Bismuth - therapeutic use
Child
Child, Preschool
Endoscopy
Female
Helicobacter Infections - drug therapy
Helicobacter Infections - epidemiology
Helicobacter Infections - immunology
Helicobacter pylori
Humans
Immunoglobulin G - immunology
Immunologic Tests
Infant
Korea - epidemiology
Male
Penicillins - therapeutic use
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Summary:The aim of this study was to evaluate the diagnostic accuracy of serologic tests and to verify whether specific IgG antibody can be used in the diagnosis of Helicobacter pylori infection in children without endoscopy. Serologic and endoscopic examinations were performed in 310 children (1 month-15 years) with gastrointestinal symptoms. Serologic outcomes were compared with the results of rapid urease test, histologic examination, and culture. The prevalence of H. pylori infection was 21.0% and the seropositivity of H. pylori was 24.2% in these symptomatic children. Serologic examination for diagnosis of H. pylori showed a sensitivity of 94.9% and a specificity of 92.4%, diagnostic reliability equal to the rapid urease test and histologic examination in children. The serum IgG test is a useful tool for the diagnosis of H. pylori infection, especially in children.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992289503400901