Application of Curdlan to Controlled Drug Delivery. III. Drug Release from Sustained Release Suppositories in Vitro

The use of curdlan, a natural β-1, 3-glucan, in the preparation of sustained release suppositories was studied in vitro. To prepare the suppositories, indomethacin, prednisolone or salbutamol sulfate was mixed with curdlan gel. Preparation conditions, including heating time and curdlan concentration...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1995/08/15, Vol.18(8), pp.1154-1158
Main Authors: KANKE, Motoko, TANABE, Emi, KATAYAMA, Hirokazu, KODA, Yoko, YOSHITOMI, Hironori
Format: Article
Language:English
Subjects:
Albuterol - administration & dosage
beta-Glucans
Biological and medical sciences
curdlan
Delayed-Action Preparations
diffusion-controlled
gel
General pharmacology
Glucans
Hot Temperature
Indomethacin - administration & dosage
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Prednisolone - administration & dosage
Suppositories
suppository
sustained release
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Summary:The use of curdlan, a natural β-1, 3-glucan, in the preparation of sustained release suppositories was studied in vitro. To prepare the suppositories, indomethacin, prednisolone or salbutamol sulfate was mixed with curdlan gel. Preparation conditions, including heating time and curdlan concentrations of 5 and 10%, had little effect on the drug release. The tonicity (hypotonic or isotonic) of the media for the suppository preparation and for in vitro drug release study also had little effect on drug release. However, the heating temperature during gel preparation, the drug amount in the suppository and the type of release media did affect drug release. It was found that drug release was sustained and diffusion-controlled in the three drugs. And finally, curdlan can be applicable for use in a sustained release suppository.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.18.1154