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Cytokines, glucocorticoids and neuroendocrine function
Activation of the immune system is normally associated with widespread alterations in neuroendocrine activity, the profile of which depends upon the species and on the severity and duration of the stimulus. Particularly important in this regard is the activation of the hypothalamo-pituitary- adrenoc...
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| Published in: | Pharmacological research 1994-07, Vol.30 (1), p.35-42 |
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| container_title | Pharmacological research |
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| creator | Buckingham, J.C. Loxley, H.D. Taylor, A.D. Flower, R.J. |
| description | Activation of the immune system is normally associated with widespread alterations in neuroendocrine activity, the profile of which depends upon the species and on the severity and duration of the stimulus. Particularly important in this regard is the activation of the hypothalamo-pituitary- adrenocortical (HPA) axis for the consequent rise in circulating glucocorticoids serves to contain the ensuing pathophysiological responses and thus to restore homeostasis. In the present study,
in vivo and
in vitro techniques have been used to examine the influence of various immunokines on the HPA axis and to determine whether their actions are modulated by glucocorticoids and lipocortin 1 (LC1).
In vivo interleukin-1/β (IL-1/β), given orally or peripherally, produced increases (
P |
| doi_str_mv | 10.1016/1043-6618(94)80085-5 |
| format | article |
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in vivo and
in vitro techniques have been used to examine the influence of various immunokines on the HPA axis and to determine whether their actions are modulated by glucocorticoids and lipocortin 1 (LC1).
In vivo interleukin-1/β (IL-1/β), given orally or peripherally, produced increases (
P<0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone. IL-1 β also produced glucocorticoid reversible increases in the release of the two corticotrophin releasing factors, CRF-41 and AVP, from the hypothalamus
in vitro (
P<0.01) as also did IL-lα, IL-6 and IL-8. By contrast, none of these cytokines influenced directly the release of ACTH from pituitary tissue
in vitro. The inhibitory actions of the glucocorticoids on the HPA responses to cytokines observed
in vivo and
in vitro were mimicked by LC1 and reversed by neutralizing anti-LC1 antisera. Our results demonstrate a role of cytokines, glucocorticoids and LC1 in effecting the interplay between the brainneuroendocrine and immune system which may be critical to host defence in conditions of both health and disease.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/1043-6618(94)80085-5</identifier><identifier>PMID: 7831193</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Annexin A1 - pharmacology ; cytokines ; Cytokines - pharmacology ; glucocorticoids ; Glucocorticoids - pharmacology ; HPA axis ; Humans ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - physiology ; hypothalamus ; Immune System - drug effects ; Immune System - physiology ; lipocortin 1 (annexin 1) ; Male ; Pituitary-Adrenal System - drug effects ; Pituitary-Adrenal System - physiology ; Rats</subject><ispartof>Pharmacological research, 1994-07, Vol.30 (1), p.35-42</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-2ec4d43a4a852fc15471d7d4f46464e08f3405dd1448cdf87a8f1c2377b53f423</citedby><cites>FETCH-LOGICAL-c447t-2ec4d43a4a852fc15471d7d4f46464e08f3405dd1448cdf87a8f1c2377b53f423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/1043661894800855$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7831193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buckingham, J.C.</creatorcontrib><creatorcontrib>Loxley, H.D.</creatorcontrib><creatorcontrib>Taylor, A.D.</creatorcontrib><creatorcontrib>Flower, R.J.</creatorcontrib><title>Cytokines, glucocorticoids and neuroendocrine function</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>Activation of the immune system is normally associated with widespread alterations in neuroendocrine activity, the profile of which depends upon the species and on the severity and duration of the stimulus. Particularly important in this regard is the activation of the hypothalamo-pituitary- adrenocortical (HPA) axis for the consequent rise in circulating glucocorticoids serves to contain the ensuing pathophysiological responses and thus to restore homeostasis. In the present study,
in vivo and
in vitro techniques have been used to examine the influence of various immunokines on the HPA axis and to determine whether their actions are modulated by glucocorticoids and lipocortin 1 (LC1).
In vivo interleukin-1/β (IL-1/β), given orally or peripherally, produced increases (
P<0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone. IL-1 β also produced glucocorticoid reversible increases in the release of the two corticotrophin releasing factors, CRF-41 and AVP, from the hypothalamus
in vitro (
P<0.01) as also did IL-lα, IL-6 and IL-8. By contrast, none of these cytokines influenced directly the release of ACTH from pituitary tissue
in vitro. The inhibitory actions of the glucocorticoids on the HPA responses to cytokines observed
in vivo and
in vitro were mimicked by LC1 and reversed by neutralizing anti-LC1 antisera. Our results demonstrate a role of cytokines, glucocorticoids and LC1 in effecting the interplay between the brainneuroendocrine and immune system which may be critical to host defence in conditions of both health and disease.</description><subject>Animals</subject><subject>Annexin A1 - pharmacology</subject><subject>cytokines</subject><subject>Cytokines - pharmacology</subject><subject>glucocorticoids</subject><subject>Glucocorticoids - pharmacology</subject><subject>HPA axis</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>hypothalamus</subject><subject>Immune System - drug effects</subject><subject>Immune System - physiology</subject><subject>lipocortin 1 (annexin 1)</subject><subject>Male</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Rats</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LxDAQxYMo67r6DRT2JApWk2aapBdBFv_Bghc9h24ykWi3WZNW2G9v6xaPMocZeO_NMD9CThm9ZpSJG0aBZ0IwdVHCpaJUFVmxR6aMliJjTIn9YR4th-QopQ9KaQmMTshEKs5YyadELLZt-PQNpqv5e92ZYEJsvQnepnnV2HmDXQzY2GBib5q7rjGtD80xOXBVnfBk7DPy9nD_unjKli-Pz4u7ZWYAZJvlaMACr6BSRe4MK0AyKy04EH0hVY4DLaxlAMpYp2SlHDM5l3JVcAc5n5Hz3d5NDF8dplavfTJY11WDoUtaSlFyWRa9EXZGE0NKEZ3eRL-u4lYzqgdcemChBxa6BP2LSw-xs3F_t1qj_QuNfHr9dqdj_-S3x6iT8dgYtD6iabUN_v8DP6bseOc</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Buckingham, J.C.</creator><creator>Loxley, H.D.</creator><creator>Taylor, A.D.</creator><creator>Flower, R.J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Cytokines, glucocorticoids and neuroendocrine function</title><author>Buckingham, J.C. ; Loxley, H.D. ; Taylor, A.D. ; Flower, R.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-2ec4d43a4a852fc15471d7d4f46464e08f3405dd1448cdf87a8f1c2377b53f423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Annexin A1 - pharmacology</topic><topic>cytokines</topic><topic>Cytokines - pharmacology</topic><topic>glucocorticoids</topic><topic>Glucocorticoids - pharmacology</topic><topic>HPA axis</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>hypothalamus</topic><topic>Immune System - drug effects</topic><topic>Immune System - physiology</topic><topic>lipocortin 1 (annexin 1)</topic><topic>Male</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buckingham, J.C.</creatorcontrib><creatorcontrib>Loxley, H.D.</creatorcontrib><creatorcontrib>Taylor, A.D.</creatorcontrib><creatorcontrib>Flower, R.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buckingham, J.C.</au><au>Loxley, H.D.</au><au>Taylor, A.D.</au><au>Flower, R.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokines, glucocorticoids and neuroendocrine function</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>30</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>Activation of the immune system is normally associated with widespread alterations in neuroendocrine activity, the profile of which depends upon the species and on the severity and duration of the stimulus. Particularly important in this regard is the activation of the hypothalamo-pituitary- adrenocortical (HPA) axis for the consequent rise in circulating glucocorticoids serves to contain the ensuing pathophysiological responses and thus to restore homeostasis. In the present study,
in vivo and
in vitro techniques have been used to examine the influence of various immunokines on the HPA axis and to determine whether their actions are modulated by glucocorticoids and lipocortin 1 (LC1).
In vivo interleukin-1/β (IL-1/β), given orally or peripherally, produced increases (
P<0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone. IL-1 β also produced glucocorticoid reversible increases in the release of the two corticotrophin releasing factors, CRF-41 and AVP, from the hypothalamus
in vitro (
P<0.01) as also did IL-lα, IL-6 and IL-8. By contrast, none of these cytokines influenced directly the release of ACTH from pituitary tissue
in vitro. The inhibitory actions of the glucocorticoids on the HPA responses to cytokines observed
in vivo and
in vitro were mimicked by LC1 and reversed by neutralizing anti-LC1 antisera. Our results demonstrate a role of cytokines, glucocorticoids and LC1 in effecting the interplay between the brainneuroendocrine and immune system which may be critical to host defence in conditions of both health and disease.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>7831193</pmid><doi>10.1016/1043-6618(94)80085-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | Pharmacological research, 1994-07, Vol.30 (1), p.35-42 |
| issn | 1043-6618 1096-1186 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Animals Annexin A1 - pharmacology cytokines Cytokines - pharmacology glucocorticoids Glucocorticoids - pharmacology HPA axis Humans Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology hypothalamus Immune System - drug effects Immune System - physiology lipocortin 1 (annexin 1) Male Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Rats |
| title | Cytokines, glucocorticoids and neuroendocrine function |
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