Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

The growth, differentiation, and development of an organism is orchestrated by the choreographed expression of a wide array of genes. The switching "on" and "off" of gene expression is the province of transcription factors, which operate singly or in association with other protei...

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Bibliographic Details
Published in:Genes & development 1995-11, Vol.9 (22), p.2723-2735
Main Authors: Verma, I M, Stevenson, J K, Schwarz, E M, Van Antwerp, D, Miyamoto, S
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Cell Nucleus
DNA-Binding Proteins - metabolism
Humans
I-kappa B Proteins
Molecular Sequence Data
NF-kappa B - metabolism
NF-KappaB Inhibitor alpha
Oligonucleotides
Oncogene Proteins v-rel
Phosphorylation
Proto-Oncogene Proteins - metabolism
Retroviridae Proteins, Oncogenic - metabolism
Signal Transduction
Transcription Factor RelB
Transcription Factors - metabolism
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Summary:The growth, differentiation, and development of an organism is orchestrated by the choreographed expression of a wide array of genes. The switching "on" and "off" of gene expression is the province of transcription factors, which operate singly or in association with other proteins. Usually transcription factors form families, where as individual members perform specific, distinct, or similar tasks. One such family includes the Rel/NF- Kappa B proteins (NF- Kappa B), which have the unique property of being sequestered in the cytoplasm in association with inhibitory proteins called I Kappa B.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.9.22.2723