Temperature change-induced potentiation: A comparative study of facilitatory mechanisms in aged and young rat hippocampal slices

The effect of temperature changes in the medium on the evoked potentials of pyramidal neurons in response to the electrical stimulation of Schaffer collaterals was investigated in both young (one to two months) and aged (24–28 months) rat hippocampal slices. Temperature increase was shown to reduce,...

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Bibliographic Details
Published in:Neuroscience 1995-09, Vol.68 (2), p.395-397
Main Authors: Buldakova, S., Dutova, E., Ivlev, S., Weiss, M.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Cold Temperature
Electric Stimulation
Hippocampus - physiology
In Vitro Techniques
Long-Term Potentiation - physiology
Pyramidal Cells - physiology
Rats
Rats, Wistar
Temperature
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Summary:The effect of temperature changes in the medium on the evoked potentials of pyramidal neurons in response to the electrical stimulation of Schaffer collaterals was investigated in both young (one to two months) and aged (24–28 months) rat hippocampal slices. Temperature increase was shown to reduce, and subsequent temperature decrease to enhance, the population spike amplitude in both young and aged rats. Temperature decrease produced a long-lasting (> 30 min) and important potentiation (180%) of population spike amplitude in young but not in aged rats. Long-term post-tetanic potentiation was maintained in young but suppressed in aged rats by temperature changes. The impairment of temperature-induced potentiation in aged rats is suggested as a tool for studying promnesic drugs.
ISSN:0306-4522
1873-7544
DOI:10.1016/0306-4522(95)00135-6