Tetrodecamycin and dihydrotetrodecamycin, new antimicrobial antibiotics against Pasteurella piscicida produced by Streptomyces nashvillensis MJ885-mF8. I: Taxonomy, fermentation, isolation, characterization and biological activities

The novel antimicrobial antibiotic against Pasteurella piscicida, tetrodecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and c...

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Bibliographic Details
Published in:Journal of antibiotics 1995, Vol.48 (10), p.1104-1109
Main Authors: TSUCHIDA, T, IINUMA, H, NISHIDA, C, KINOSHITA, N, SAWA, T, HAMADA, M, TAKEUCHI, T
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Fermentation
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
Medical sciences
Mice
Microbial Sensitivity Tests
Molecular Structure
Pasteurella - drug effects
Pharmacology. Drug treatments
Streptomyces - classification
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Summary:The novel antimicrobial antibiotic against Pasteurella piscicida, tetrodecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and crystallization. The MICs of 1 were 6.25 approximately 12.5 micrograms/liter and 1.56 approximately 6.25 micrograms/ml against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and 12 strains of P. piscicida, respectively.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.1104