New anthracycline antibiotics 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin

Two new anthracycline antibiotics, 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin, were photochemically obtained from anthracycline metabolites D788-1 (10-carboxy-13-deoxocarminomy-cin) and D788-3 (10-carboxy-11-deoxy-13-deoxocarminomycin) and were examined for their growth inhibitory activities...

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Bibliographic Details
Published in:Journal of antibiotics 1995, Vol.48 (10), p.1153-1158
Main Authors: JOHDO, O, NISHIDA, H, OKAMOTO, R, YOSHIMOTO, A, TAKEUCHI, T
Format: Article
Language:English
Subjects:
Animals
Anthracyclines - chemical synthesis
Anthracyclines - chemistry
Anthracyclines - pharmacology
Antibiotics, Antineoplastic - chemical synthesis
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - pharmacology
Antineoplastic agents
Biological and medical sciences
Chromatography, High Pressure Liquid
General aspects
Leukemia L1210
Medical sciences
Molecular Conformation
Pharmacology. Drug treatments
Structure-Activity Relationship
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Description
Summary:Two new anthracycline antibiotics, 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin, were photochemically obtained from anthracycline metabolites D788-1 (10-carboxy-13-deoxocarminomy-cin) and D788-3 (10-carboxy-11-deoxy-13-deoxocarminomycin) and were examined for their growth inhibitory activities on cultured L1210 leukemic cells. Effects of the S configuration of C-10 and a hydroxyl group at C-11 on the bioactivity are discussed in comparison with oxaunomycin and 11-deoxyoxaunomycin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.1153