Urticaria associated with thyrotoxicosis

Summary We report a patient with chronic urticaria which was closely associated with elevated levels of thyroxine. The urticaria responded poorly to antihistamines and only partially to systemic steroids, but resolved consistently when the thyroxine level was reduced to normal. The mechanism for the...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental dermatology 1995-03, Vol.20 (2), p.173-174
Main Authors: HENDERSON, C. A., HIGHET, A. S.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carbimazole - therapeutic use
Chronic Disease
Endocrinopathies
Female
Humans
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Thyroid. Thyroid axis (diseases)
Thyrotoxicosis - complications
Thyrotoxicosis - diagnosis
Thyrotoxicosis - drug therapy
Thyroxine - blood
Urticaria - blood
Urticaria - complications
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary We report a patient with chronic urticaria which was closely associated with elevated levels of thyroxine. The urticaria responded poorly to antihistamines and only partially to systemic steroids, but resolved consistently when the thyroxine level was reduced to normal. The mechanism for the association may involve modulation of the cyclic AMP levels within mast cells. The association between thyrotoxicosis and urticaria was reported as early as 1966. More recent reports have concentrated on the increased frequency of chronic urticaria in those with thyroid autoantibodies.1–3 These cases were unrelated to abnormal levels of thyroid hormones. We report a case showing a close association between urticaria and hyperthyroidism, and discuss the possible mechanisms contributing to the relationship between thyroid disease and urticaria.
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.1995.tb02678.x