Fulminant hepatitis due to Epstein-Barr virus infection

Epstein-Barr virus infection is a benign disease, which may occasionally be fatal, particularly in children. Epstein-Barr virus infection is rare in elderly subjects and appears to have a self-limited course. An unusual case of fulminant hepatitis due to primary Epstein-Barr virus infection in a 62-...

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Bibliographic Details
Published in:Journal of hepatology 1995-09, Vol.23 (3), p.348-350
Main Authors: Papatheodoridis, George V., Delladetsima, Johanna K., Kavallierou, Lilian, Kapranos, Nikiforos, Tassopoulos, Nicolaos C.
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Epstein-Barr virus
Fatal Outcome
Fulminant hepatitis
Hepatitis, Viral, Human - pathology
Hepatitis, Viral, Human - virology
Herpesviridae Infections - pathology
Herpesvirus 4, Human
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Post-transfusion hepatitis
Viral diseases
Viral diseases of the digestive system
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Summary:Epstein-Barr virus infection is a benign disease, which may occasionally be fatal, particularly in children. Epstein-Barr virus infection is rare in elderly subjects and appears to have a self-limited course. An unusual case of fulminant hepatitis due to primary Epstein-Barr virus infection in a 62-year-old male 18 days after a cardiosurgical operation and blood transfusions is described in the present paper. Post-mortem examination of the liver showed massive hepatic necrosis. The etiology was established by increase in IgM antibodies to Epstein-Barr virus (titer 1:3.120) in serum and by cellular expression of Epstein-Barr virus DNA in liver tissue.
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(95)80015-8