nucleotide sequence of the 5'non-coding and capsid coding genome regions of two bovine enterovirus strains

The sequence of cDNA clones representing the 5 non-coding regions (NCR) and capsid regions of two bovine enteroviruses (strains PS-87 and RM-2; serotype two viruses) have been determined and compared with that obtained from a serotype one strain (VG-5-27). All three strains showed a longer 5' N...

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Bibliographic Details
Published in:Archives of virology 1994, Vol.139 (3/4), p.287-299
Main Authors: McNally, R.M.P, Earle, J.A.P, McIlhatton, M, Hoey, E.M, Martin, S.J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
amino acid sequences
Animals
Base Sequence
Biological and medical sciences
Bovine enterovirus
Capsid - chemistry
Capsid - genetics
Cattle
Cloning, Molecular
coat proteins
Codon
DNA, Complementary - genetics
DNA, Viral - genetics
embl/x79368
embl/x79369
Enterovirus - genetics
Fundamental and applied biological sciences. Psychology
Genetics
Genome, Viral
Microbiology
molecular conformation
Molecular Sequence Data
Nucleic Acid Conformation
nucleotide sequences
Open Reading Frames
Sequence Alignment
strain differences
Virology
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Summary:The sequence of cDNA clones representing the 5 non-coding regions (NCR) and capsid regions of two bovine enteroviruses (strains PS-87 and RM-2; serotype two viruses) have been determined and compared with that obtained from a serotype one strain (VG-5-27). All three strains showed a longer 5' NCR compared to human enteroviruses and rhinoviruses due in part to a hundred residue insertion approximately at a hundred residues in from the 5' end. However, another domain occurring at nucleotide 187-222 in poliovirus is absent in each bovine enterovirus. Comparisons of the predicted structural protein amino acid sequences indicate that PS-87 shares most sequence identity with RM-2 and then with VG-5-27 in that order. The VP1 protein of PS-87 and RM-2 are shorter than the equivalent VP1 of VG-5-27 due in part to a truncation at their C-terminii. VP3 is only slightly smaller than VP2 in each virus.
ISSN:0304-8608
1432-8798