Physical and genetic mapping of human chromosome 3 loci containing microsatellite repeats

One hundred and six microsatellite repeat-containing loci, including 59 CA-containing repeats from the CEPH/Genethon collection, were regionally assigned on human chromosome 3 using a somatic cell hybrid mapping panel, diving the chromosome into 14 intervals. The others were dinucleotide and tetranu...

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Bibliographic Details
Published in:Chromosome research 1994-11, Vol.2 (6), p.423-427
Main Authors: Gerken, S, Whisenant, E, Varkony, T, Todd, S, Gemmill, R, Jones, C, Weissenbach, J, Matsunami, N, Moore, M, Lawrence, E
Format: Article
Language:English
Subjects:
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 3
DNA Primers
DNA, Satellite - analysis
DNA, Satellite - genetics
Humans
Lymphocytes - metabolism
Male
Molecular Sequence Data
Oligonucleotide Probes
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid
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Summary:One hundred and six microsatellite repeat-containing loci, including 59 CA-containing repeats from the CEPH/Genethon collection, were regionally assigned on human chromosome 3 using a somatic cell hybrid mapping panel, diving the chromosome into 14 intervals. The others were dinucleotide and tetranucleotide repeat-containing loci newly developed for human chromosome 3, of which 26 were also localized by means of genetic linkage analysis against selected CEPH microsatellites. The regional assignment of these two marker sets in a common mapping panel facilitates their integration. Incorporation of these highly polymorphic loci into the developing physical and genetic maps should provide useful information for studies of various diseases involving chromosome 3.
ISSN:0967-3849
1573-6849
DOI:10.1007/BF01552864