ISOLATION AND CHARACTERIZATION OF A NEW 12-MEMBERED MACROLIDE FD-895

During the course of our screening program for natural product drugs effective against multidrug resistant cells by using adriamycin resistant HL-60 cells, we have discovered a new 12 membered macrolide FD-895 in the fermentation broth of Streptomyces hygroscopicus A-9561 isolated from a soil sample...

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Bibliographic Details
Published in:Journal of antibiotics 1994/12/25, Vol.47(12), pp.1395-1401
Main Authors: SEKI-ASANO, MITSUKO, OKAZAKI, TADAYASU, YAMAGISHI, MICHIO, SAKAI, NORIYOSHI, TAKAYAMA, YASUKO, HANADA, KAZUNORI, MORIMORO, SIGEO, Takatsuki, AKIRA, Mizoue, KAZUNORI
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Drug Screening Assays, Antitumor
Fermentation
HeLa Cells
Humans
Macrolides
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Microscopy, Electron, Scanning
Molecular Structure
Pharmacology. Drug treatments
Streptomyces - metabolism
Streptomyces - ultrastructure
Streptomyces hygroscopicus
Tumor Cells, Cultured
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Summary:During the course of our screening program for natural product drugs effective against multidrug resistant cells by using adriamycin resistant HL-60 cells, we have discovered a new 12 membered macrolide FD-895 in the fermentation broth of Streptomyces hygroscopicus A-9561 isolated from a soil sample collected at Iriomote Island, Okinawa prefecture, Japan. FD-895 showed stronger cytocidal activities against in vitro tumor cell lines than adriamycin. FD-895 had the same IC50 values against parent and adriamycin resistant HL-60 cells.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.47.1395