DNA Amplification of HER-2/neu and INT-2 Oncogenes in Epithelial Ovarian Cancer

Objective: Oncogene alterations are thought to be prognostic indices in patients with breast cancer. The present study was carried out to investigate the amplification of the HER-2/neu and INT-2 oncogenes in ovarian cancer. Methods: In a retrospective study of 196 patients with epithelial ovarian ca...

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Bibliographic Details
Published in:Gynecologic oncology 1995-12, Vol.59 (3), p.321-326
Main Authors: Medl, Michael, Sevelda, Paul, Czerwenka, Klaus, Dobianer, Karl, Hanak, Hanns, Hruza, Christa, Klein, Matthias, Leodolter, Sepp, Müllauer-Ertl, Susanne, Rosen, Alexander, Salzer, Heinrich, Vavra, Norbert, Spona, Jürgen
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Base Sequence
Biological and medical sciences
DNA, Neoplasm - genetics
Female
Female genital diseases
Fibroblast Growth Factor 3
Fibroblast Growth Factors - genetics
Gene Amplification
Genes, erbB-2
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Middle Aged
Molecular Probes - genetics
Molecular Sequence Data
Ovarian Neoplasms - genetics
Ovarian Neoplasms - mortality
Proto-Oncogene Proteins - genetics
Retrospective Studies
Survival Analysis
Tumors
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Summary:Objective: Oncogene alterations are thought to be prognostic indices in patients with breast cancer. The present study was carried out to investigate the amplification of the HER-2/neu and INT-2 oncogenes in ovarian cancer. Methods: In a retrospective study of 196 patients with epithelial ovarian cancer, the amplification of the oncogenes HER-2/neu and INT-2 in the DNA of paraffin-embedded tumor cells was determined by quantitative PCR. The purpose of this study was to analyze whether the two oncogenes correlated with such predictive factors as FIGO stage, histological grade, ascites, postoperative residual tumor mass, hormone receptor content, and preoperative CA 125 serum levels. The effect of HER-2/neu and INT-2 amplification on patient survival was also studied. Results: The only correlation found in this study was between INT-2 and preoperative CA 125 levels (P= 0.03). No correlations were demonstrable between HER-2/neu (log-rank test;P= 0.67) and INT-2 (log-rank test;P= 0.75) amplifications and overall survival. Conclusion: Unlike the established prognostic factors, neither HER-2/neu nor INT-2 appears to be predictive for survival in patients with ovarian cancer.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.1995.9969