Prolactin and rapid eye movement sleep regulation

During the past few years data have accumulated suggesting the involvement of prolactin (PRL) in rapid eye movement sleep (REMS) regulation. Pituitary PRL secretion seems to be, at least in part, sleep-dependent. PRL is also found in the central nervous system. PRL-containing neurons in the hypothal...

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Published in:Sleep (New York, N.Y.) N.Y.), 1995-09, Vol.18 (7), p.536-542
Main Authors: ROKY, R, OBAL, F. JR, VALATX, J.-L, BREDOW, S, JIDONG FANG, PAGANO, L.-P, KRUEGER, J. K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cats
Circadian Rhythm
Fundamental and applied biological sciences. Psychology
Pituitary Gland - secretion
Prolactin - blood
Prolactin - secretion
Rabbits
Rats
Sleep, REM - physiology
Sleep. Vigilance
Vertebrates: nervous system and sense organs
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container_end_page 542
container_issue 7
container_start_page 536
container_title Sleep (New York, N.Y.)
container_volume 18
creator ROKY, R
OBAL, F. JR
VALATX, J.-L
BREDOW, S
JIDONG FANG
PAGANO, L.-P
KRUEGER, J. K
description During the past few years data have accumulated suggesting the involvement of prolactin (PRL) in rapid eye movement sleep (REMS) regulation. Pituitary PRL secretion seems to be, at least in part, sleep-dependent. PRL is also found in the central nervous system. PRL-containing neurons in the hypothalamus project to various structures in the brain. Systemic injection of PRL promotes REMS in rats, cats and rabbits. Intracerebroventricular injection of PRL enhances REMS in rats. Stimulation of endogenous PRL secretion by vasoactive intestinal peptide (VIP) also promotes REMS. Immunoneutralization of blood-borne PRL slightly reduces REMS. Various observations (hypoprolactinemic and hyperprolactinemic rats) indicate that PRL may act on REMS via modulating the diurnal rhythms of REMS. It is likely that hypothalamic PRL is more important for sleep regulation than circulating PRL. Hypothalamic PRL is likely involved in the mediation of the REMS-promoting activity of VIP. We conclude that PRL has a role in REMS regulation.
doi_str_mv 10.1093/sleep/18.7.536
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subjects Animals
Biological and medical sciences
Cats
Circadian Rhythm
Fundamental and applied biological sciences. Psychology
Pituitary Gland - secretion
Prolactin - blood
Prolactin - secretion
Rabbits
Rats
Sleep, REM - physiology
Sleep. Vigilance
Vertebrates: nervous system and sense organs
title Prolactin and rapid eye movement sleep regulation
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