Effects of Hypericum Extract on the Expression of Serotonin Receptors

The influence of hypericum extract LI 160 on the expression of serotonin receptors was investigated using a neuroblastoma cell line to establish a model for the regulation of neurotransmitters by immunologically active compounds such as cytokines. The cells were incubated with hypericum extract LI 1...

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Bibliographic Details
Published in:Journal of geriatric psychiatry and neurology 1994-10, Vol.7 (1), p.63-64
Main Authors: Müller, W.E.G., Rossol, R.
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - pharmacology
Hypericum
Interleukin-1 - pharmacology
Neuroblastoma
Perylene - analogs & derivatives
Perylene - pharmacology
Plant Extracts - pharmacology
Plants, Medicinal
Quercetin - analogs & derivatives
Quercetin - pharmacology
Rats
Receptors, Serotonin - analysis
Receptors, Serotonin - drug effects
Serotonin Antagonists - pharmacology
Tumor Cells, Cultured
Xanthenes - pharmacology
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Summary:The influence of hypericum extract LI 160 on the expression of serotonin receptors was investigated using a neuroblastoma cell line to establish a model for the regulation of neurotransmitters by immunologically active compounds such as cytokines. The cells were incubated with hypericum extract LI 160 in kinetic form for 2, 4, 6, 8, and 10 hours, then washed. The serotonin receptor expression analysis was compared to that of a placebo control solution. The neuroblastoma cells showed a clearly reduced expression of the serotonin receptors under treatment with hypericum extract. First stimulation experiments with interleukin-1 (IL-1) and hypericum extract suggest that a further reduction of the serotonin receptors is possible when IL-1 is added.
ISSN:0891-9887
1552-5708
DOI:10.1177/089198879400700117