Normal Growth and Pubertal Development During Bromocriptine Therapy in Two Patients with Prolactinoma

The cases of two boys, a 14 years 10 months old and an 18-year-old, with delayed puberty are presented. The first patient also had a short stature. Both patients had a pituitary adenoma, as shown by computed tomography, with high prolactin levels. After bromocriptine therapy was started, there was a...

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Bibliographic Details
Published in:Endocrine Journal 1995, Vol.42(4), pp.581-586
Main Authors: KAMEL, NURI, UYSAL, ALI RIZA, CESUR, VEDIA, ERDOAN, GÜRBÜZ, BASKAL, NILCÜN
Format: Article
Language:English
Subjects:
Adolescent
Bromocriptine
Bromocriptine - therapeutic use
Dopamine Agonists - therapeutic use
Humans
Male
Pituitary Neoplasms - blood
Pituitary Neoplasms - drug therapy
Pituitary Neoplasms - physiopathology
Prolactin - blood
Prolactinoma
Prolactinoma - blood
Prolactinoma - drug therapy
Prolactinoma - physiopathology
Puberty
Puberty - drug effects
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Summary:The cases of two boys, a 14 years 10 months old and an 18-year-old, with delayed puberty are presented. The first patient also had a short stature. Both patients had a pituitary adenoma, as shown by computed tomography, with high prolactin levels. After bromocriptine therapy was started, there was a spontaneous progression of normal puberty. The first patient used a synthetic growth hormone together with bromocriptine, however, even after the growth hormone was stopped progression in puberty and gain in height continued. The favorable response obtained in these patients implies that bromocriptine can be an effective therapy for adolescent patients with prolactinoma.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.42.581