Polymorphic tri- and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene

Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The different alleles were detected by a method combining fluorescence labeling of polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although...

Full description

Saved in:
Bibliographic Details
Published in:Human genetics 1995-12, Vol.96 (6), p.737-738
Main Authors: MALFROY, L, VIRATELLE, C, COPPIN, H, BOROT, N, ROTH, M. P
Format: Article
Language:English
Subjects:
Alleles
Base Sequence
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
DNA Primers
Exons
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Linkage
Genetic Variation
Genetics of eukaryotes. Biological and molecular evolution
Hemochromatosis - genetics
Human
Humans
Male
Molecular Sequence Data
Multiple Sclerosis - genetics
Myelin Proteins
Myelin-Associated Glycoprotein - genetics
Myelin-Oligodendrocyte Glycoprotein
Oligodendroglia - metabolism
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The different alleles were detected by a method combining fluorescence labeling of polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although only two alleles differing by the number of leucine residues encoded by the (CTC)n array were detected at the first locus, seven alleles were identified at the second. The high degree of polymorphism (75%) of the tetranucleotide repeat makes this marker informative for association or linkage studies with diseases such as hemochromatosis or multiple sclerosis.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00210310