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Polymorphic tri- and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene
Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The different alleles were detected by a method combining fluorescence labeling of polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although...
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| Published in: | Human genetics 1995-12, Vol.96 (6), p.737-738 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c257t-4f59ef7291eb2097d682762e9b7b9e0cb77150a3692bf7c8cb7060017fc0362b3 |
| container_end_page | 738 |
| container_issue | 6 |
| container_start_page | 737 |
| container_title | Human genetics |
| container_volume | 96 |
| creator | MALFROY, L VIRATELLE, C COPPIN, H BOROT, N ROTH, M. P |
| description | Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The different alleles were detected by a method combining fluorescence labeling of polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although only two alleles differing by the number of leucine residues encoded by the (CTC)n array were detected at the first locus, seven alleles were identified at the second. The high degree of polymorphism (75%) of the tetranucleotide repeat makes this marker informative for association or linkage studies with diseases such as hemochromatosis or multiple sclerosis. |
| doi_str_mv | 10.1007/BF00210310 |
| format | article |
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The high degree of polymorphism (75%) of the tetranucleotide repeat makes this marker informative for association or linkage studies with diseases such as hemochromatosis or multiple sclerosis.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/BF00210310</identifier><identifier>PMID: 8522338</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Alleles ; Base Sequence ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; DNA Primers ; Exons ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetic Linkage ; Genetic Variation ; Genetics of eukaryotes. Biological and molecular evolution ; Hemochromatosis - genetics ; Human ; Humans ; Male ; Molecular Sequence Data ; Multiple Sclerosis - genetics ; Myelin Proteins ; Myelin-Associated Glycoprotein - genetics ; Myelin-Oligodendrocyte Glycoprotein ; Oligodendroglia - metabolism ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Repetitive Sequences, Nucleic Acid</subject><ispartof>Human genetics, 1995-12, Vol.96 (6), p.737-738</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c257t-4f59ef7291eb2097d682762e9b7b9e0cb77150a3692bf7c8cb7060017fc0362b3</citedby><cites>FETCH-LOGICAL-c257t-4f59ef7291eb2097d682762e9b7b9e0cb77150a3692bf7c8cb7060017fc0362b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2921689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8522338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MALFROY, L</creatorcontrib><creatorcontrib>VIRATELLE, C</creatorcontrib><creatorcontrib>COPPIN, H</creatorcontrib><creatorcontrib>BOROT, N</creatorcontrib><creatorcontrib>ROTH, M. P</creatorcontrib><title>Polymorphic tri- and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The different alleles were detected by a method combining fluorescence labeling of polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although only two alleles differing by the number of leucine residues encoded by the (CTC)n array were detected at the first locus, seven alleles were identified at the second. The high degree of polymorphism (75%) of the tetranucleotide repeat makes this marker informative for association or linkage studies with diseases such as hemochromatosis or multiple sclerosis.</description><subject>Alleles</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA Primers</subject><subject>Exons</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetic Linkage</subject><subject>Genetic Variation</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Hemochromatosis - genetics</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Multiple Sclerosis - genetics</subject><subject>Myelin Proteins</subject><subject>Myelin-Associated Glycoprotein - genetics</subject><subject>Myelin-Oligodendrocyte Glycoprotein</subject><subject>Oligodendroglia - metabolism</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Repetitive Sequences, Nucleic Acid</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkc1P3DAQxa0KRBfaS--VfEAVIIWOx5s4PlLElwSih_YcOc5kCXLixfZK5L_HLSs4chpp3k9PM-8x9k3AqQBQP39dAqAAKeATW4ilxEIgyB22ALmEolJCfWb7MT4CiFJjucf26hJRynrB4m_v5tGH9cNgeQpDwc3U8UQpmGljHfk0dMQDrcmkyIeJ07OfIhf_sZr7nqcH4uNMLmveDSvf0dQFb-dEfOVm69fBJ8ri0d391TFf0URf2G5vXKSv23nA_l5e_Dm_Lm7vr27Oz24Li6VKxbIvNfUKtaAWQauuqlFVSLpVrSawrVKiBCMrjW2vbJ0XUOUXVW9BVtjKA_bj1Tef8LShmJpxiJacMxP5TWyUUjmDHMRHoFCAWEvI4MkraIOPMVDfrMMwmjA3App_VTTvVWT4-9Z1047UvaHb7LN-uNVNtMb1OXE7xDcMNYqq1vIFTAWPIQ</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>MALFROY, L</creator><creator>VIRATELLE, C</creator><creator>COPPIN, H</creator><creator>BOROT, N</creator><creator>ROTH, M. 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Biological and molecular evolution</topic><topic>Hemochromatosis - genetics</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Multiple Sclerosis - genetics</topic><topic>Myelin Proteins</topic><topic>Myelin-Associated Glycoprotein - genetics</topic><topic>Myelin-Oligodendrocyte Glycoprotein</topic><topic>Oligodendroglia - metabolism</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Repetitive Sequences, Nucleic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MALFROY, L</creatorcontrib><creatorcontrib>VIRATELLE, C</creatorcontrib><creatorcontrib>COPPIN, H</creatorcontrib><creatorcontrib>BOROT, N</creatorcontrib><creatorcontrib>ROTH, M. 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P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphic tri- and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>1995-12</date><risdate>1995</risdate><volume>96</volume><issue>6</issue><spage>737</spage><epage>738</epage><pages>737-738</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The different alleles were detected by a method combining fluorescence labeling of polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although only two alleles differing by the number of leucine residues encoded by the (CTC)n array were detected at the first locus, seven alleles were identified at the second. The high degree of polymorphism (75%) of the tetranucleotide repeat makes this marker informative for association or linkage studies with diseases such as hemochromatosis or multiple sclerosis.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>8522338</pmid><doi>10.1007/BF00210310</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6717 |
| ispartof | Human genetics, 1995-12, Vol.96 (6), p.737-738 |
| issn | 0340-6717 1432-1203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77733822 |
| source | Springer Online Journal Archives (Through 1996) |
| subjects | Alleles Base Sequence Biological and medical sciences Classical genetics, quantitative genetics, hybrids DNA Primers Exons Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Linkage Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Hemochromatosis - genetics Human Humans Male Molecular Sequence Data Multiple Sclerosis - genetics Myelin Proteins Myelin-Associated Glycoprotein - genetics Myelin-Oligodendrocyte Glycoprotein Oligodendroglia - metabolism Polymerase Chain Reaction Polymorphism, Genetic Repetitive Sequences, Nucleic Acid |
| title | Polymorphic tri- and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene |
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