Cloning, Characterization, and Genetic Mapping of the Rat Type 2 Angiotensin II Receptor Gene

The renin-angiotensin system plays an important role in blood pressure homeostasis, but the contribution of the type 2 angiotensin II receptor (AT2 R) is still unclear. The reports that the AT2 R gene has been mapped to the X chromosome in human and rat and the previous report of a gene, Bp3, on the...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1995-12, Vol.26 (6), p.998-1002
Main Authors: Koike, George, Winer, Eric S, Horiuchi, Masatsugu, Brown, Donna M, Szpirer, Claude, Dzau, Victor J, Jacob, Howard J
Format: Article
Language:English
Subjects:
Alleles
Angiotensin II - genetics
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Cloning, Molecular
Endocrine kidney. Renin-angiotensin-aldosterone system
Fundamental and applied biological sciences. Psychology
Genes
Genetic Markers
Genomic Library
Hypertension - genetics
In Situ Hybridization, Fluorescence
Molecular Sequence Data
Rats
Rats, Inbred SHR - genetics
Rats, Inbred Strains - genetics
Rats, Inbred WKY - genetics
Rats, Sprague-Dawley - genetics
Receptors, Angiotensin - genetics
Transcription, Genetic
Vertebrates: endocrinology
X Chromosome - genetics
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Summary:The renin-angiotensin system plays an important role in blood pressure homeostasis, but the contribution of the type 2 angiotensin II receptor (AT2 R) is still unclear. The reports that the AT2 R gene has been mapped to the X chromosome in human and rat and the previous report of a gene, Bp3, on the X chromosome responsible for an increase in blood pressure have suggested that the rat AT2 R gene (Agtr2) could be this gene. To elucidate whether Agtr2 is Bp3, Agtr2 was cloned. A simple sequence repeat in the 3'-flanking region of this gene was identified and used as a genetic marker to map Agtr2 to the X chromosome at 18.1 cM distal to the androgen receptor locus. This map position is outside the confidence interval reported for Bp3, demonstrating that Agtr2 cannot be Bp3. However, these data will enhance the research into the AT2 R biology as well as the study of the X chromosome. (Hypertension. 1995;26[part 1]:998-1002.)
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.26.6.998