Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation

N6-Cyclopentyladenosine (CPA), an A1 adenosine receptor agonist, increased EEG slow-wave activity in nonREM sleep when administered either systemically (0.1-3 mg/kg) or intracerebroventricularly (3.5-10 micrograms) in the rat. The power spectrum of EEG changes (as calculated by Fourier analysis) mat...

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Bibliographic Details
Published in:Brain research 1995-09, Vol.692 (1-2), p.79-85
Main Authors: BENINGTON, J. H, KODALI, S. K, HELLER, H. C
Format: Article
Language:English
Subjects:
Adenosine - administration & dosage
Adenosine - analogs & derivatives
Adenosine - pharmacology
Adenosine - physiology
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Dose-Response Relationship, Drug
Electroencephalography - drug effects
Fourier Analysis
Fundamental and applied biological sciences. Psychology
Injections, Intraventricular
Male
Purinergic P1 Receptor Agonists
Rats
Rats, Wistar
Sleep Deprivation - physiology
Sleep, REM - physiology
Sleep. Vigilance
Vertebrates: nervous system and sense organs
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Summary:N6-Cyclopentyladenosine (CPA), an A1 adenosine receptor agonist, increased EEG slow-wave activity in nonREM sleep when administered either systemically (0.1-3 mg/kg) or intracerebroventricularly (3.5-10 micrograms) in the rat. The power spectrum of EEG changes (as calculated by Fourier analysis) matched that produced by total sleep deprivation in the rat. The effects of CPA on the nonREM-sleep EEG were dose-dependent. These findings suggest that adenosine is an endogenous mediator of sleep-deprivation induced increases in EEG slow-wave activity, and therefore that increased adenosine release is a concomitant of accumulation of sleep need and may be involved in homeostatic feedback control of sleep expression.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(95)00590-m