Correlations between periovulatory serum and follicular fluid CA-125 and granulosa cell hormones after controlled ovarian hyperstimulation

Objective: To determine the presence and concentration of CA-125 in periovulatory follicular fluid (FF) and serum after controlled ovarian hyperstimulation and to determine if the CA-125 in these two compartments could be related to granulosa cell markers such as inhibin or estradiol. Study Design:...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 1995-09, Vol.62 (1), p.95-99
Main Authors: Saraf, Varsha K., O'Neill, Margaret, Riccioli, Anthony, Penha, P.Daniel, Obasaju, Michael F., Josimovich, John B.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
CA-125
CA-125 Antigen - blood
CA-125 Antigen - metabolism
Embryo Transfer
Estradiol - blood
Estradiol - metabolism
Female
Fertilization in Vitro
Follicle Stimulating Hormone - blood
Follicle Stimulating Hormone - metabolism
Follicular fluid
Follicular Fluid - metabolism
Genital system. Mammary gland
Granulosa Cells - metabolism
Hormones - metabolism
Humans
Inhibin
Inhibins - blood
Inhibins - metabolism
Investigative techniques, diagnostic techniques (general aspects)
IVF-ET
Medical sciences
Ovulation - physiology
Ovulation Induction
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
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Summary:Objective: To determine the presence and concentration of CA-125 in periovulatory follicular fluid (FF) and serum after controlled ovarian hyperstimulation and to determine if the CA-125 in these two compartments could be related to granulosa cell markers such as inhibin or estradiol. Study Design: Fifteen women undergoing controlled ovarian hyperstimulation for in-vitro fertilization-embryo transfer were studied. A transvaginal, ultrasound-guided follicular aspiration was performed. CA-125, inhibin, estradiol and FSH were measured in FF and serum. Pearson and Spearman's Rank Correlation tests were performed. Results: CA-125 was measurable in 59% of follicles. Values ranged from undetectable to 3630 U/ml. Serum CA-125 ranged from undetectable to 126 U/ml. CA-125 and inhibin correlated negatively in FF and positively in serum. Conclusion: CA-125 was present in significant but variable concentrations in 59% of periovulatory follicles. A negative correlation was noted between CA-125 and inhibin or estradiol in the FF and a positive correlation with serum inhibin. No correlations were noted to oocyte retrieval or fertilization.
ISSN:0301-2115
1872-7654
DOI:10.1016/0301-2115(95)02168-7