Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy

Radical prostatectomy is one treatment for organ-confined prostatic adenocarcinoma. Dissemination of malignant prostatic cells after radical prostatectomy could be partly due to prostate manipulation during dissection. We confirmed by assay of prostate-specific membrane antigen by reverse-transcript...

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Bibliographic Details
Published in:The Lancet (British edition) 1995-12, Vol.346 (8989), p.1528-1530
Main Authors: Eschwège, P, Blanchet, P, Benoit, G, Jardin, A, Dumas, F, Le Maire, V, Lacour, B, Loric, S
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - surgery
Aged
Biological and medical sciences
Humans
Male
Medical research
Medical sciences
Middle Aged
Neoplasm Seeding
Neoplastic Cells, Circulating
Polymerase Chain Reaction - methods
Postoperative Period
Prostate cancer
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Neoplasms - blood
Prostatic Neoplasms - surgery
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
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Summary:Radical prostatectomy is one treatment for organ-confined prostatic adenocarcinoma. Dissemination of malignant prostatic cells after radical prostatectomy could be partly due to prostate manipulation during dissection. We confirmed by assay of prostate-specific membrane antigen by reverse-transcription nested PCR that prostate manipulation seeded prostatic epithelial cells in the general circulation in 12 of 14 consecutive patients operated on for organ-confined prostate adenocarcinoma. Our results suggest that surgeons should approach radical prostatectomy with care to avoid seeding from the prostate gland. Antiandrogen therapy might reduce the haematogenous spread of prostatic cells during radical prostatectomy.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(95)92054-4