Do nitric oxide and cGMP play a role in calcium cycling?

The biological molecule NO and its cyclic nucleotide effector molecule cGMP, are involved in a variety of biological systems. This article reviews evidence supporting a role for these molecules in signal transduction. Over the last 10 years, it has become evident that these molecules are important i...

Full description

Saved in:
Bibliographic Details
Published in:Cell Calcium 1995-09, Vol.18 (3), p.207-213
Main Authors: Milbourne, E.A., Bygrave, F.L.
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Cyclic GMP - physiology
Ion Transport
Nitric Oxide - physiology
Signal Transduction - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The biological molecule NO and its cyclic nucleotide effector molecule cGMP, are involved in a variety of biological systems. This article reviews evidence supporting a role for these molecules in signal transduction. Over the last 10 years, it has become evident that these molecules are important in Ca 2+ regulation, particularly in excitable cells. In these cells, cGMP-dependent mechanisms appear to both directly and indirectly regulate Ca 2+ transport. Until recently, reports of the actions of cGIVIP in non-excitable cells have been contradictory, presenting a confusing plethora of effects. In these cells, the cGMP-Ca 2+ regulation pathway appears to be concentration-dependent, possibly representing a negative feedback mechanism. Ca 2+ entry appears to be activated when low concentrations of cGMP are present, and inhibited at higher concentrations. The role of cGMIP in Ca 2+ regulation in non-excitable cells has been largely overlooked and further investigation of this issue may provide clues as to the nature of various unknown components that induce Ca 2+ entry into these cells.
ISSN:0143-4160
1532-1991
DOI:10.1016/0143-4160(95)90065-9