The elemental principles of calcium signaling

Ca super(2+) is a ubiquitous intracellular signaling molecule controlling a wide array of cellular processes, including secretion, contraction, and cell proliferation. In resting cells, the intracellular Ca super(2+) concentration ([Ca super(2+)] sub(i)) is maintained at approximately 10-100 nM, and...

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Bibliographic Details
Published in:Cell 1995-12, Vol.83 (5), p.675-678
Main Authors: Bootman, Martin D., Berridge, Michael J.
Format: Article
Language:English
Subjects:
Animals
Calcium - physiology
Calcium Channels - physiology
Inositol 1,4,5-Trisphosphate Receptors
Muscle Proteins - physiology
Receptors, Cytoplasmic and Nuclear - physiology
Ryanodine Receptor Calcium Release Channel
Signal Transduction - physiology
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Summary:Ca super(2+) is a ubiquitous intracellular signaling molecule controlling a wide array of cellular processes, including secretion, contraction, and cell proliferation. In resting cells, the intracellular Ca super(2+) concentration ([Ca super(2+)] sub(i)) is maintained at approximately 10-100 nM, and during stimulation the average [Ca super(2+)] sub(i) can rise up to several micromolar, depending on the cell type. Such Ca super(2+) signals have a complex temporal and spatial arrangement, although the mechanisms underlying the complexity are not entirely clear. Since information is encoded in the spatiotemporal patterns of these intracellular signals, much interest is now focused on how these complex Ca super(2+) signals are generated.
ISSN:0092-8674
1097-4172
DOI:10.1016/0092-8674(95)90179-5