In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE)

Traditional medicines reported to be used as anti-hypertensives or diuretics from different regions in the world (China, India and South America) have been investigated. The bioassay is based on inhibition of ACE, as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substr...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1995-08, Vol.48 (1), p.43-51
Main Authors: Hansen, Klaus, Nyman, Ulf, Smitt, Ulla Wagner, Adsersen, Anne, Gudiksen, Lene, Rajasekharan, Sreedharan, Pushpangadan, Palpu
Format: Article
Language:English
Subjects:
ACE
Angiotensin converting enzyme
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Anti-hypertensive
Antihypertensive Agents - pharmacology
Bioassay
Biological and medical sciences
Chromatography, High Pressure Liquid
Dansyl Compounds - analysis
Diuretic
Drug Evaluation, Preclinical
General pharmacology
Medical sciences
Medicine, Traditional
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - analysis
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Traditional medicine
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Summary:Traditional medicines reported to be used as anti-hypertensives or diuretics from different regions in the world (China, India and South America) have been investigated. The bioassay is based on inhibition of ACE, as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. In total, 31 species have been investigated and the crude extracts from seven species inhibit the enzyme by more than 50%.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(95)01286-M