Defensive reflexes of the respiratory system in anaesthetized rabbits during high frequency jet ventilation

The defensive airway reflexes during high frequency jet ventilation (HFJV) were studied in anaesthetized, non-vagotomized (n = 16) and vagotomized (n = 11) rabbits. The animals were ventilated by a high frequency jet ventilator. Sneezing and coughing were evoked by mechanical stimulation of the airw...

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Bibliographic Details
Published in:Experimental physiology 1994-11, Vol.79 (6), p.967-973
Main Authors: Javorka, K, Kulisek, V, Calkovska, A
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - physiology
Bronchi - physiology
Cough - physiopathology
High-Frequency Jet Ventilation
Physical Stimulation
Rabbits
Reflex - physiology
Respiratory Physiological Phenomena
Sneezing - physiology
Trachea - physiology
Vagus Nerve - physiology
Vagus Nerve - surgery
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Summary:The defensive airway reflexes during high frequency jet ventilation (HFJV) were studied in anaesthetized, non-vagotomized (n = 16) and vagotomized (n = 11) rabbits. The animals were ventilated by a high frequency jet ventilator. Sneezing and coughing were evoked by mechanical stimulation of the airways. During HFJV spontaneous breathing was inhibited only in the non-vagotomized rabbits. Mechanical stimulation of the airways during HFJV evoked sneezing and coughing, in which the inspiratory component was inhibited. This inhibition occurred not only in defensive reflexes evoked from the regions with increased pressure (trachea, bronchi), but also from the nose. Vagotomy diminished but did not fully eliminate the changes in sneezing accompanying HFJV. The intensity of maximum expiratory efforts was not significantly affected by HFJV in both subgroups.
ISSN:0958-0670
1469-445X
DOI:10.1113/expphysiol.1994.sp003821