Association of Estrogen Receptor Dinucleotide Repeat Polymorphism with Osteoporosis

We investigated the association between dinucleotide (thymine-adenine) repeat polymorphism lying upstream of human estrogen receptor (ER) gene and bone mineral density (BMD) as well as biochemical markers for bone metabolism in 144 healthy postmenopausal Japanese women. The genotype was classified i...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1995-12, Vol.217 (1), p.378-383
Main Authors: Sano, M., Inoue, S., Hosoi, T., Ouchi, Y., Emi, M., Shiraki, M., Orimo, H.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
Base Sequence
Bone Density - genetics
Dinucleotide Repeats
DNA Primers - genetics
Female
Gene Frequency
Genetic Markers
Genotype
Humans
Middle Aged
Molecular Sequence Data
Osteoporosis, Postmenopausal - genetics
Osteoporosis, Postmenopausal - metabolism
Polymorphism, Genetic
Receptors, Estrogen - genetics
Risk Factors
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Summary:We investigated the association between dinucleotide (thymine-adenine) repeat polymorphism lying upstream of human estrogen receptor (ER) gene and bone mineral density (BMD) as well as biochemical markers for bone metabolism in 144 healthy postmenopausal Japanese women. The genotype was classified into "A" through "R" according to the number of the repeats, from 10 to 27. BMD was expressed in Z score (a deviation from the weight-adjusted average BMD of each age using the standard deviation as a unit). The people having genotype C (12 repeats of thymine-adenine) allele (n=15) had significantly lower Z score of spine BMD (mean ± SD; −1.11 ± 1.3 vs. −0.06 ± 1.2; p
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1995.2787