Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis

Extravasation of host's leukocytes from blood vessels into inflammatory tissues represents a prerequisite for a subsequent interaction with invaded parasites. The migratory responses of eosinophilic and neutrophilic granulocytes in the polar forms of the filarial infection onchocerciasis were i...

Full description

Saved in:
Bibliographic Details
Published in:Acta tropica 1995-09, Vol.60 (1), p.21-33
Main Authors: de Krömer, M.T.Rubio, Medina-De la Garza, C.E., Brattig, N.W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Chemotaxis
Chemotaxis, Leukocyte - physiology
Diseases caused by nematodes
Eosinophils
Eosinophils - physiology
Female
Filariases
Helminthic diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
N-Formylmethionine Leucyl-Phenylalanine
Neutrophilic granulocytes
Neutrophils - physiology
Onchocerciasis
Onchocerciasis - classification
Onchocerciasis - immunology
Onchocercosis
Parasitic diseases
Platelet Activating Factor
Tropical medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Extravasation of host's leukocytes from blood vessels into inflammatory tissues represents a prerequisite for a subsequent interaction with invaded parasites. The migratory responses of eosinophilic and neutrophilic granulocytes in the polar forms of the filarial infection onchocerciasis were investigated. The hyporeactive, generalized form, the chronic hyperreactive (sowda) form and persons without signs of onchocerciasis from a hypoendemic area for onchocerciasis were compared. Eusinophils from sowda patients responded more strongly to the inflammatory mediator platelet-activating factor (PAF) than those from generalized patients and persons without onchocerciasis. The most significant differences were found between the sowda group and a subgroup of the generalized form with 16–80 microfilariae/mg skin ( P
ISSN:0001-706X
1873-6254
DOI:10.1016/0001-706X(95)00099-Z