Expression of Fimbriae and Host Response in Branhamella catarrhalis Respiratory Infections

Sputum during the acute exacerbation of chronic respiratory diseases were observed under the electron microscope, to determine the in vivo expression of surface structures of Branhamella catarrhalis (B. catarrhalis), the polymorphonuclear neutrophil (PMN) response to B. catarrhalis infections, and t...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1994, Vol.38(10), pp.767-771
Main Authors: Ahmed, Kamruddin, Masaki, Hironori, Dai, Iran Cong, Ichinose, Akitoyo, Utsunomiya, Yoshiaki, Tao, Misao, Nagatake, Tsuyoshi, Matsumoto, Keizo
Format: Article
Language:English
Subjects:
Adult
Aged
Bacterial diseases
Bacterial diseases of the respiratory system
Biological and medical sciences
Branhamella catarrhalis
Bronchiectasis - microbiology
Bronchiectasis - pathology
Bronchitis - microbiology
Bronchitis - pathology
Chronic Disease
Female
Fimbriae
Fimbriae, Bacterial - ultrastructure
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Moraxella (Branhamella) catarrhalis - isolation & purification
Moraxella (Branhamella) catarrhalis - ultrastructure
Neisseriaceae Infections - microbiology
Neisseriaceae Infections - pathology
Neutrophils - microbiology
Neutrophils - physiology
Phagocytosis - physiology
Sputum
Sputum - cytology
Sputum - microbiology
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Summary:Sputum during the acute exacerbation of chronic respiratory diseases were observed under the electron microscope, to determine the in vivo expression of surface structures of Branhamella catarrhalis (B. catarrhalis), the polymorphonuclear neutrophil (PMN) response to B. catarrhalis infections, and the composition of sputum. It was found that during infection fimbriae are expressed in B. catarrhalis. However, there were sparsely to densely fimbriated bacteria in each sputum sample. The length of the fimbriae were from 50 to 76nm. In the sparsely fimbriated B. catarrhalis, external to the cell wall, a thin, granular, electron-dense layer was observed. Due to the presence of fimbriae, this layer was not seen in densely fimbriated B. catarrhalis. Blebs were also found in B. catarrhalis. PMNs were found to phagocytose both B. catarrhalis and debris. Evidence was found that debris were formed mainly by the destruction of PMNs. Bacteria as well as debris were phagocytosed by PMNs.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1994.tb01855.x