Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats : similarities to clozapine

Seroquel (ICI 204,636) is a mixed D2/5HT2 antagonist with a preclinical profile suggestive of potential antipsychotic efficacy. We compared seroquel to clozapine in an animal model of sensorimotor gating deficits in shizophrenic patients. Like schizophrenic patients, rats treated with apomophrine (A...

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Published in:Psychopharmacologia 1994-05, Vol.114 (4), p.675-678
Main Authors: SWERDLOW, N. R, ZISOOK, D, TAAID, N
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Animals
Antipsychotic Agents - pharmacology
Apomorphine - antagonists & inhibitors
Apomorphine - pharmacology
Biological and medical sciences
Clozapine - pharmacology
Dibenzothiazepines - pharmacology
Dose-Response Relationship, Drug
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Quetiapine Fumarate
Rats
Rats, Sprague-Dawley
Reflex, Startle - drug effects
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description Seroquel (ICI 204,636) is a mixed D2/5HT2 antagonist with a preclinical profile suggestive of potential antipsychotic efficacy. We compared seroquel to clozapine in an animal model of sensorimotor gating deficits in shizophrenic patients. Like schizophrenic patients, rats treated with apomophrine (APO) exhibit deficits in prepulse inhibition (PPI) of acoustic startle. The ability of antipsychotics to restore PPI in APO-treated rats correlates (Rs = 0.991) with their clinical potency. Seroquel and clozapine both restore PPI in APO-treated rats. Seroquel's restoration of PPI in apomorphine-treated rats follows simple monotonic ascending dose-response properties, and is not accompanied by consistent changes in startle reflex amplitude. Seroquel's profile in this PPI model mimics that of other antipsychotics.
doi_str_mv 10.1007/BF02245001
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source Springer Online Journal Archives
subjects Acoustic Stimulation
Animals
Antipsychotic Agents - pharmacology
Apomorphine - antagonists & inhibitors
Apomorphine - pharmacology
Biological and medical sciences
Clozapine - pharmacology
Dibenzothiazepines - pharmacology
Dose-Response Relationship, Drug
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Quetiapine Fumarate
Rats
Rats, Sprague-Dawley
Reflex, Startle - drug effects
title Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats : similarities to clozapine
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