A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: Preliminary findings

Brain morphological abnormalities have been reported in several independent investigations of chronic schizophrenic patients. The present study is a prospective 4-year follow-up of first-episode schizophrenic patients to determine whether some of these abnormalities may be a consequence of regional...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1995-09, Vol.38 (6), p.349-360
Main Authors: DeLisi, Lynn E., Tew, William, Xie, Shu-hong, Hoff, Anne L., Sakuma, Michael, Kushner, Maureen, Lee, Gregory, Shedlack, Karen, Smith, Angela M., Grimson, Roger
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain - pathology
brain morphology
Cognition - physiology
Female
First-episode schizophrenia
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Prospective Studies
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - pathology
Schizophrenia - physiopathology
Schizophrenic Psychology
ventricular enlargement
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Summary:Brain morphological abnormalities have been reported in several independent investigations of chronic schizophrenic patients. The present study is a prospective 4-year follow-up of first-episode schizophrenic patients to determine whether some of these abnormalities may be a consequence of regional brain structural change over time after the onset of a first psychotic episode. Whole hemisphere, temporal lobes, superior temporal gyrus, hippocampus, caudate, corpus callosum, and lateral ventricles were measured in a series of MRI scans taken over a 4-year period in 20 patients and five controls. Total volume reduction was noted in both hemispheres to a greater degree in patients than controls. When adjusted for total brain size, left ventricular enlargement occurred in patients, but not controls, over time. These preliminary data suggest that subtle cortical atrophy may be occurring over time after the onset of illness.
ISSN:0006-3223
1873-2402
DOI:10.1016/0006-3223(94)00376-E