Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent (2): Effect of Acteoside on Leukocyte Accumulation in the Glomeruli of Nephritic Rats

We investigated the effect of acteoside in comparison with that of cyclosporin A on leukocyte accumulation in the glomeruli of rats with crescentic-type anti-glomerular basement membrane (GBM) nephritis. Acteoside given p.o. at a dose of 30 mg/kg once a day for 15 consecutive days after treatment wi...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1994, Vol.66(1), pp.47-52
Main Authors: Hayashi, Kazumi, Nagamatsu, Tadashi, Ito, Mikio, Hattori, Tomohisa, Suzuki, Yoshio
Format: Article
Language:English
Subjects:
Acteoside
Animals
Biological and medical sciences
Crescentic-type anti-GBM nephritis
Cyclosporine - pharmacology
gamma-Globulins - immunology
Glomerulonephritis - drug therapy
Glomerulonephritis - pathology
Glucosides - therapeutic use
Immunohistochemistry
Immunomodulators
Immunosuppressive Agents - therapeutic use
Kidney Glomerulus - pathology
Leukocyte
Leukocyte Count - drug effects
Leukocytes - drug effects
Male
Medical sciences
Pharmacology. Drug treatments
Phenols
Plants, Medicinal - chemistry
Proteinuria - drug therapy
Rats
Rats, Sprague-Dawley
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Summary:We investigated the effect of acteoside in comparison with that of cyclosporin A on leukocyte accumulation in the glomeruli of rats with crescentic-type anti-glomerular basement membrane (GBM) nephritis. Acteoside given p.o. at a dose of 30 mg/kg once a day for 15 consecutive days after treatment with anti-GBM serum markedly suppressed the urinary protein as well as glomerular histological changes. Acteoside given p.o. for 5 or 15 consecutive days markedly suppressed the accumulation of total leukocytes, ED-1-positive cells (monocyles/macrophages), CD4-positive cells, CD8-positive cells, interleukin-2-receptor-positive cells (activated T cells) and la-positive cells in the glomeruli. These effects of cyclosporin A (20 mg/kg/day, p.o.) were also as potent as those of acteoside (30 mg/kg/day, p.o.). Cyclosporin A also strongly suppressed the elevation of plasma antibody level against rabbit γ-globulin. However, in this dose, acteoside did not significantly suppress the antibody formation. It can be concluded from these results that acteoside may exert its antinephritic action by suppressing the accumulation of leukocytes in the glomeruli.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.66.47