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The role of psychological coronary risk factors in insulin and glucose metabolism

The association between psychological coronary risk factors and serum insulin, and C-peptide and blood glucose concentrations, [the latter measured while fasting and during the oral glucose tolerance test (OGTT)], was examined in healthy middle-aged men ( n=64). The results indicate that among the e...

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Bibliographic Details
Published in:Journal of psychosomatic research 1994-10, Vol.38 (7), p.705-713
Main Authors: Räikkönen, Katri, Keltikangas-Järvinen, Liisa, Hautanen, Aarno
Format: Article
Language:English
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Summary:The association between psychological coronary risk factors and serum insulin, and C-peptide and blood glucose concentrations, [the latter measured while fasting and during the oral glucose tolerance test (OGTT)], was examined in healthy middle-aged men ( n=64). The results indicate that among the evaluated psychological risk factors, high levels of hostile paranoia and vital exhaustion were most consistently associated with an enhanced insulin/glucose ratio, and enhanced insulin, C-peptide and glucose responses during OGTT. The associations persisted after controlling for age, smoking, alcohol consumption and visceral fat distribution. Thus, in addition to age, life-style factors and obesity, psychological factors may have an effect on insulin and glucose metabolism.
ISSN:0022-3999
1879-1360
DOI:10.1016/0022-3999(94)90023-X