Significantly lower prevalence of Helicobacter pylori in uremic patients than in patients with normal renal function

The objective of the study was to evaluate the prevalence of Helicobacter pylori in patients with different degrees of renal function. Two hundred and twenty consecutive patients requiring gastroscopy for upper intestinal symptoms were enrolled in the study: group I (normal renal function, n = 127),...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology 1995-10, Vol.30 (5), p.585-588
Main Authors: Jaspersen, D, Fassbinder, W, Heinkele, P, Kronsbein, H, Schorr, W, Raschka, C, Brennenstuhl, M
Format: Article
Language:English
Subjects:
Biopsy
Gastritis - complications
Gastritis - epidemiology
Gastroscopy
Helicobacter Infections - complications
Helicobacter Infections - epidemiology
Helicobacter pylori - isolation & purification
Humans
Middle Aged
Prevalence
Renal Dialysis
Retrospective Studies
Uremia - complications
Uremia - microbiology
Uremia - therapy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of the study was to evaluate the prevalence of Helicobacter pylori in patients with different degrees of renal function. Two hundred and twenty consecutive patients requiring gastroscopy for upper intestinal symptoms were enrolled in the study: group I (normal renal function, n = 127), group II (chronic renal failure, creatinine clearance > 5 < 90 ml/min, n = 59), and group III (hemodialysis therapy, n = 34). On endoscopy, biopsy specimens were taken for analysis of H. pylori infection by urease test and histology. The prevalence of H. pylori in patients with renal dysfunction proved to be significantly lower than that in patients with normal renal function (22.6% vs 37%, P < 0.05). The incidence of ulcer disease in patients with normal renal function was higher than that in uremic patients (14.2% vs 10.8%, not significant). These findings indicate that uremic patients seem to be partly protected against H. pylori infection.
ISSN:0944-1174
DOI:10.1007/BF02367783