Gummiferol, a Cytotoxic Polyacetylene from the Leaves of Adenia gummifera

A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1995-10, Vol.58 (10), p.1625-1628
Main Authors: Fullas, Fekadu, Brown, Daniel M, Wani, Mansukh C, Wall, Monroe R, Chagwedera, Tangai E, Farnsworth, Norman R, Pezzuto, John M, Kinghorn, A. Douglas
Format: Article
Language:English
Subjects:
Acetates - chemistry
Acetates - isolation & purification
Acetates - pharmacology
AGENTES ANTINEOPLASTICOS
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CYTOTOXIC COMPOUNDS
ESPECTROMETRIA
Fatty Alcohols - chemistry
Fatty Alcohols - isolation & purification
Fatty Alcohols - pharmacology
FEUILLE
General pharmacology
HIDROCARBUROS
HOJAS
HUMAN CANCER CELL LINES
Humans
HYDROCARBONS
HYDROCARBURE
KB HUMAN CELL LINES
LEAVES
Magnetic Resonance Spectroscopy
Medical sciences
MEDICAMENT CYTOSTATIQUE
MOLECULAR CONFORMATION
MOLECULAR STRUCTURE
NEOPLASMAS
NEOPLASME
NEOPLASMS
PASSIFLORACEAE
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
Tumor Cells, Cultured
ZIMBABWE
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structure of 1 was established primarily on the basis of its spectral data.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50124a027