DETECTION OF 1-ACETAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL AS A NEW METABOLITE OF PROPRANOLOL

1-Acetamino-3-(1-naphthyloxy)-2-propanol which is an acetyl conjugate of N-desisopropylpropranolol (AcNDP) was detected as a new metabolite of propranolol (PL) from the incubation medium of isolated rat hepatocyte system and from the urinary extracts of a patient under PL therapy as well as a health...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1994/10/15, Vol.17(10), pp.1433-1435
Main Authors: NODA, Atsuko, ONO, Yoko, INOKUCHI, Kae, ETO, Seiji, NODA, Hiroshi, MURO, Hideki, UCHIDA, Takahiro
Format: Article
Language:English
Subjects:
Acetamides - metabolism
Acetamides - urine
acetyl conjugate
Aged
Animals
Antihypertensive agents
Biological and medical sciences
Cardiovascular system
Chromatography, High Pressure Liquid
Female
Gas Chromatography-Mass Spectrometry
human urine
Humans
Liver - cytology
Liver - metabolism
Male
Medical sciences
Methylcholanthrene - pharmacology
Middle Aged
Oxidation-Reduction
Pharmacology. Drug treatments
Phenobarbital - pharmacology
Propanolamines - metabolism
Propanolamines - urine
Propranolol - metabolism
Propranolol - therapeutic use
propranolol metabolite
rat hepatocyte
Rats
Rats, Wistar
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Summary:1-Acetamino-3-(1-naphthyloxy)-2-propanol which is an acetyl conjugate of N-desisopropylpropranolol (AcNDP) was detected as a new metabolite of propranolol (PL) from the incubation medium of isolated rat hepatocyte system and from the urinary extracts of a patient under PL therapy as well as a healthy volunteer given PL. In the case of the hepatocyte systems, the optical selectivity of PL elimination and the metabolite formation were discussed by HPLC determination, and the effect of pretreatment by phenobarbital (PB) or 3-metylcholanthrene (3-MC) on the metabolism was also clarified.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.17.1433