The effect of Chinese medicinal herb Zingiberis rhizoma extract on cytokine secretion by human peripheral blood mononuclear cells

The ethanolic extract of the Chinese medicinal herb Zingiberis rhizoma, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), was found to show biphasic effects on secretion of cytokines by human peripheral blood mononuclear cells in vitro. In this study, the augmentative effect of Zingiberis r...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1995-08, Vol.48 (1), p.13-19
Main Authors: Chang, Chih-Peng, Chang, Jan-Yi, Wang, Fang-Yu, Chang, Jan-Gowth
Format: Article
Language:English
Subjects:
Augmentative effect
Biological and medical sciences
chinese traditional medicines
colony-stimulating factors
Cytokine
Cytokines - biosynthesis
Drugs, Chinese Herbal - analysis
Drugs, Chinese Herbal - pharmacology
General pharmacology
granulocyte-macrophage colony-stimulating factor
Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis
Humans
In Vitro Techniques
interleukin 1 beta
interleukin-1
Interleukin-1 - biosynthesis
interleukin-6
interleukins
Lipopolysaccharides - analysis
Medical sciences
monocytes
Neutrophils - drug effects
Neutrophils - metabolism
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
plant extracts
rhizomes
secretion
Stimulation, Chemical
traditional medicine
Tumor Necrosis Factor-alpha - biosynthesis
tumor necrosis factors
Zingiber officinale
Zingiberis rhizoma
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Summary:The ethanolic extract of the Chinese medicinal herb Zingiberis rhizoma, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), was found to show biphasic effects on secretion of cytokines by human peripheral blood mononuclear cells in vitro. In this study, the augmentative effect of Zingiberis rhizoma extract on cytokine secretion was shown to be time dependent. No significant secretion of cytokine was noted when the reaction time was 1 or 3 h. Secretion of interleukin-1β (IL-1β), interleukin-6 (IL-6), and granulocyte-macrophage colony-stimulating factor (GM-CSF) by the mononuclear cells was markedly increased in the presence of a low concentration of Zingiberis rhizoma extract, varying from 10–30 mg/ml, when the reaction time was 18 or 24 h. A higher concentration of the herbal extract did not show similar or stronger augmentative effect as did low concentration of the herbal extract.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(95)01275-I