Intact Delay-Eyeblink Classical Conditioning in Amnesia

The status of classical conditioning in human amnesia was examined by comparing conditioning of the eyeblink response (the unconditional response) to a tone conditioned stimulus (CS) paired with an airpuff unconditioned stimulus (US) in the delay paradigm between 7 amnesic and 7 age-and education-ma...

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Bibliographic Details
Published in:Behavioral neuroscience 1995-10, Vol.109 (5), p.819-827
Main Authors: Gabrieli, John D. E, McGlinchey-Berroth, Regina, Carrillo, Maria C, Gluck, Mark A, Cermak, Laird S, Disterhoft, John F
Format: Article
Language:English
Subjects:
Adult
Aged
Amnesia
Amnesia - physiopathology
Association Learning - physiology
Associative Processes
Behavior
Brain
Brain - physiopathology
Brain Damage, Chronic - physiopathology
Brain Mapping
Conditioning, Classical - physiology
Conditioning, Eyelid - physiology
Extinction (Learning)
Extinction, Psychological - physiology
Eyeblink Reflex
Eyelid Conditioning
Female
Human
Humans
Learning
Male
Memory
Mental Recall - physiology
Middle Aged
Reaction Time - physiology
Reference Values
Stimulus Parameters
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Summary:The status of classical conditioning in human amnesia was examined by comparing conditioning of the eyeblink response (the unconditional response) to a tone conditioned stimulus (CS) paired with an airpuff unconditioned stimulus (US) in the delay paradigm between 7 amnesic and 7 age-and education-matched normal control participants. Amnesic patients exhibited normal baseline performance in pseudoconditioning and normal acquisition and extinction of conditioned responses in terms of the number, latency, and magnitude of eyeblinks. These results indicate that in humans, as in rabbits, brain structures critical for declarative memory are not essential for the acquisition of elementary CS-US associations.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.109.5.819