Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats

While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar (i.pl.) in...

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Bibliographic Details
Published in:European journal of pharmacology 1995-09, Vol.284 (3), p.321-325
Main Authors: Jackson, Douglass L., Graff, Christopher B., Richardson, Jennelle Durnett, Hargreaves, Kenneth M.
Format: Article
Language:English
Subjects:
6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
Analgesia
Animals
Biological and medical sciences
Body Temperature - drug effects
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione)
Dizocilpine Maleate - pharmacology
Fundamental and applied biological sciences. Psychology
Glutamate
Glutamic Acid - pharmacology
Hot Temperature
Hyperalgesia
Inflammation
Male
MK-801
Pain
Rats
Rats, Sprague-Dawley
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Vertebrates: nervous system and sense organs
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Summary:While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar (i.pl.) injection of l-glutamate (30 nmol) evokes a thermal hyperalgesic response in the paw withdrawal latencies of normal rats which is stereospecific. In addition, the i.pl. injection of either the non-competitive N-methyl- d-aspartate (NMDA) receptor antagonist MK-801 (10 nmol) acid (AMPA)/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (100 nmol) into hindpaws inflamed with carrageenan significantly reduced the thermal hyperalgesic response in rats. Collectively, these results suggest that excitatory amino acids activate a peripheral target which facilitates a hyperalgesic behavioral response to thermal stimulation via a receptor mediated process.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(95)00449-U