An STS-Based Map of the Human Genome

A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases. The project involved assembly of a radiation hybrid map of the human genome containing 6193 loci and incorporated a genetic linkage map of the human genom...

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Published in:Science (American Association for the Advancement of Science) 1995-12, Vol.270 (5244), p.1945-1954
Main Authors: Hudson, Thomas J., Stein, Lincoln D., Gerety, Sebastian S., Ma, Junli, Castle, Andrew B., Silva, James, Slonim, Donna K., Baptista, Rafael, Kruglyak, Leonid, Xu, Shu-Hua, Hu, Xintong, Angela M. E. Colbert, Rosenberg, Carl, Reeve-Daly, Mary Pat, Rozen, Steve, Hui, Lester, Wu, Xiaoyun, Vestergaard, Christina, Wilson, Kimberly M., Bae, Jane S., Maitra, Shanak, Ganiatsas, Soula, Evans, Cheryl A., DeAngelis, Margaret M., Ingalls, Kimberly A., Nahf, Robert W., Horton, Lloyd T., Anderson, Michele Oskin, Collymore, Alville J., Ye, Wenjuan, Kouyoumjian, Vardouhie, Zemsteva, Irena S., Tam, James, Devine, Richard, Courtney, Dorothy F., Renaud, Michelle Turner, Nguyen, Huy, O'Connor, Tara J., Fizames, Cécile, Fauré, Sabine, Gyapay, Gabor, Dib, Colette, Morissette, Jean, Orlin, James B., Birren, Bruce W., Goodman, Nathan, Weissenbach, Jean, Hawkins, Trevor L., Foote, Simon, Page, David C., Lander, Eric S.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Line
Chromosome Mapping
Chromosomes
Chromosomes, Artificial, Yeast
Classical genetics, quantitative genetics, hybrids
Databases, Factual
Fundamental and applied biological sciences. Psychology
Gene Expression
Genetic loci
Genetic mapping
Genetic Markers
Genetic screening
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human
Genomes
Genomics
Human
Human genetics
Human genome
Human Genome Project
Humans
Hybrid Cells
Libraries
Polymerase Chain Reaction
Science and Society
Sequence Analysis, DNA
Sequence Tagged Sites
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cited_by cdi_FETCH-LOGICAL-c837t-d24d8ba6cc64a683d257556d5a5249f5b86c5a6aa62e0f36db3616234577ac7a3
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container_end_page 1954
container_issue 5244
container_start_page 1945
container_title Science (American Association for the Advancement of Science)
container_volume 270
creator Hudson, Thomas J.
Stein, Lincoln D.
Gerety, Sebastian S.
Ma, Junli
Castle, Andrew B.
Silva, James
Slonim, Donna K.
Baptista, Rafael
Kruglyak, Leonid
Xu, Shu-Hua
Hu, Xintong
Angela M. E. Colbert
Rosenberg, Carl
Reeve-Daly, Mary Pat
Rozen, Steve
Hui, Lester
Wu, Xiaoyun
Vestergaard, Christina
Wilson, Kimberly M.
Bae, Jane S.
Maitra, Shanak
Ganiatsas, Soula
Evans, Cheryl A.
DeAngelis, Margaret M.
Ingalls, Kimberly A.
Nahf, Robert W.
Horton, Lloyd T.
Anderson, Michele Oskin
Collymore, Alville J.
Ye, Wenjuan
Kouyoumjian, Vardouhie
Zemsteva, Irena S.
Tam, James
Devine, Richard
Courtney, Dorothy F.
Renaud, Michelle Turner
Nguyen, Huy
O'Connor, Tara J.
Fizames, Cécile
Fauré, Sabine
Gyapay, Gabor
Dib, Colette
Morissette, Jean
Orlin, James B.
Birren, Bruce W.
Goodman, Nathan
Weissenbach, Jean
Hawkins, Trevor L.
Foote, Simon
Page, David C.
Lander, Eric S.
description A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases. The project involved assembly of a radiation hybrid map of the human genome containing 6193 loci and incorporated a genetic linkage map of the human genome containing 5264 loci. This information was combined with the results of STS-content screening of 10,850 loci against a yeast artificial chromosome library to produce an integrated map, anchored by the radiation hybrid and genetic maps. The map provides radiation hybrid coverage of 99 percent and physical coverage of 94 percent of the human genome. The map also represents an early step in an international project to generate a transcript map of the human genome, with more than 3235 expressed sequences localized. The STSs in the map provide a scaffold for initiating large-scale sequencing of the human genome.
doi_str_mv 10.1126/science.270.5244.1945
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E. Colbert ; Rosenberg, Carl ; Reeve-Daly, Mary Pat ; Rozen, Steve ; Hui, Lester ; Wu, Xiaoyun ; Vestergaard, Christina ; Wilson, Kimberly M. ; Bae, Jane S. ; Maitra, Shanak ; Ganiatsas, Soula ; Evans, Cheryl A. ; DeAngelis, Margaret M. ; Ingalls, Kimberly A. ; Nahf, Robert W. ; Horton, Lloyd T. ; Anderson, Michele Oskin ; Collymore, Alville J. ; Ye, Wenjuan ; Kouyoumjian, Vardouhie ; Zemsteva, Irena S. ; Tam, James ; Devine, Richard ; Courtney, Dorothy F. ; Renaud, Michelle Turner ; Nguyen, Huy ; O'Connor, Tara J. ; Fizames, Cécile ; Fauré, Sabine ; Gyapay, Gabor ; Dib, Colette ; Morissette, Jean ; Orlin, James B. ; Birren, Bruce W. ; Goodman, Nathan ; Weissenbach, Jean ; Hawkins, Trevor L. ; Foote, Simon ; Page, David C. ; Lander, Eric S.</creator><creatorcontrib>Hudson, Thomas J. ; Stein, Lincoln D. ; Gerety, Sebastian S. ; Ma, Junli ; Castle, Andrew B. ; Silva, James ; Slonim, Donna K. ; Baptista, Rafael ; Kruglyak, Leonid ; Xu, Shu-Hua ; Hu, Xintong ; Angela M. E. Colbert ; Rosenberg, Carl ; Reeve-Daly, Mary Pat ; Rozen, Steve ; Hui, Lester ; Wu, Xiaoyun ; Vestergaard, Christina ; Wilson, Kimberly M. ; Bae, Jane S. ; Maitra, Shanak ; Ganiatsas, Soula ; Evans, Cheryl A. ; DeAngelis, Margaret M. ; Ingalls, Kimberly A. ; Nahf, Robert W. ; Horton, Lloyd T. ; Anderson, Michele Oskin ; Collymore, Alville J. ; Ye, Wenjuan ; Kouyoumjian, Vardouhie ; Zemsteva, Irena S. ; Tam, James ; Devine, Richard ; Courtney, Dorothy F. ; Renaud, Michelle Turner ; Nguyen, Huy ; O'Connor, Tara J. ; Fizames, Cécile ; Fauré, Sabine ; Gyapay, Gabor ; Dib, Colette ; Morissette, Jean ; Orlin, James B. ; Birren, Bruce W. ; Goodman, Nathan ; Weissenbach, Jean ; Hawkins, Trevor L. ; Foote, Simon ; Page, David C. ; Lander, Eric S.</creatorcontrib><description>A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases. The project involved assembly of a radiation hybrid map of the human genome containing 6193 loci and incorporated a genetic linkage map of the human genome containing 5264 loci. This information was combined with the results of STS-content screening of 10,850 loci against a yeast artificial chromosome library to produce an integrated map, anchored by the radiation hybrid and genetic maps. The map provides radiation hybrid coverage of 99 percent and physical coverage of 94 percent of the human genome. The map also represents an early step in an international project to generate a transcript map of the human genome, with more than 3235 expressed sequences localized. 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Biological and molecular evolution ; Genome, Human ; Genomes ; Genomics ; Human ; Human genetics ; Human genome ; Human Genome Project ; Humans ; Hybrid Cells ; Libraries ; Polymerase Chain Reaction ; Science and Society ; Sequence Analysis, DNA ; Sequence Tagged Sites</subject><ispartof>Science (American Association for the Advancement of Science), 1995-12, Vol.270 (5244), p.1945-1954</ispartof><rights>Copyright 1995 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1995 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Dec 22, 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c837t-d24d8ba6cc64a683d257556d5a5249f5b86c5a6aa62e0f36db3616234577ac7a3</citedby><cites>FETCH-LOGICAL-c837t-d24d8ba6cc64a683d257556d5a5249f5b86c5a6aa62e0f36db3616234577ac7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/213569837/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/213569837?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2884,2885,21378,21394,27924,27925,33611,33612,33877,33878,43733,43880,58238,58471,74221,74397</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2938326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8533086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hudson, Thomas J.</creatorcontrib><creatorcontrib>Stein, Lincoln D.</creatorcontrib><creatorcontrib>Gerety, Sebastian S.</creatorcontrib><creatorcontrib>Ma, Junli</creatorcontrib><creatorcontrib>Castle, Andrew B.</creatorcontrib><creatorcontrib>Silva, James</creatorcontrib><creatorcontrib>Slonim, Donna K.</creatorcontrib><creatorcontrib>Baptista, Rafael</creatorcontrib><creatorcontrib>Kruglyak, Leonid</creatorcontrib><creatorcontrib>Xu, Shu-Hua</creatorcontrib><creatorcontrib>Hu, Xintong</creatorcontrib><creatorcontrib>Angela M. E. Colbert</creatorcontrib><creatorcontrib>Rosenberg, Carl</creatorcontrib><creatorcontrib>Reeve-Daly, Mary Pat</creatorcontrib><creatorcontrib>Rozen, Steve</creatorcontrib><creatorcontrib>Hui, Lester</creatorcontrib><creatorcontrib>Wu, Xiaoyun</creatorcontrib><creatorcontrib>Vestergaard, Christina</creatorcontrib><creatorcontrib>Wilson, Kimberly M.</creatorcontrib><creatorcontrib>Bae, Jane S.</creatorcontrib><creatorcontrib>Maitra, Shanak</creatorcontrib><creatorcontrib>Ganiatsas, Soula</creatorcontrib><creatorcontrib>Evans, Cheryl A.</creatorcontrib><creatorcontrib>DeAngelis, Margaret M.</creatorcontrib><creatorcontrib>Ingalls, Kimberly A.</creatorcontrib><creatorcontrib>Nahf, Robert W.</creatorcontrib><creatorcontrib>Horton, Lloyd T.</creatorcontrib><creatorcontrib>Anderson, Michele Oskin</creatorcontrib><creatorcontrib>Collymore, Alville J.</creatorcontrib><creatorcontrib>Ye, Wenjuan</creatorcontrib><creatorcontrib>Kouyoumjian, Vardouhie</creatorcontrib><creatorcontrib>Zemsteva, Irena S.</creatorcontrib><creatorcontrib>Tam, James</creatorcontrib><creatorcontrib>Devine, Richard</creatorcontrib><creatorcontrib>Courtney, Dorothy F.</creatorcontrib><creatorcontrib>Renaud, Michelle Turner</creatorcontrib><creatorcontrib>Nguyen, Huy</creatorcontrib><creatorcontrib>O'Connor, Tara J.</creatorcontrib><creatorcontrib>Fizames, Cécile</creatorcontrib><creatorcontrib>Fauré, Sabine</creatorcontrib><creatorcontrib>Gyapay, Gabor</creatorcontrib><creatorcontrib>Dib, Colette</creatorcontrib><creatorcontrib>Morissette, Jean</creatorcontrib><creatorcontrib>Orlin, James B.</creatorcontrib><creatorcontrib>Birren, Bruce W.</creatorcontrib><creatorcontrib>Goodman, Nathan</creatorcontrib><creatorcontrib>Weissenbach, Jean</creatorcontrib><creatorcontrib>Hawkins, Trevor L.</creatorcontrib><creatorcontrib>Foote, Simon</creatorcontrib><creatorcontrib>Page, David C.</creatorcontrib><creatorcontrib>Lander, Eric S.</creatorcontrib><title>An STS-Based Map of the Human Genome</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases. The project involved assembly of a radiation hybrid map of the human genome containing 6193 loci and incorporated a genetic linkage map of the human genome containing 5264 loci. This information was combined with the results of STS-content screening of 10,850 loci against a yeast artificial chromosome library to produce an integrated map, anchored by the radiation hybrid and genetic maps. The map provides radiation hybrid coverage of 99 percent and physical coverage of 94 percent of the human genome. The map also represents an early step in an international project to generate a transcript map of the human genome, with more than 3235 expressed sequences localized. The STSs in the map provide a scaffold for initiating large-scale sequencing of the human genome.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes, Artificial, Yeast</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Databases, Factual</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genetic loci</subject><subject>Genetic mapping</subject><subject>Genetic Markers</subject><subject>Genetic screening</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Human</subject><subject>Human genetics</subject><subject>Human genome</subject><subject>Human Genome Project</subject><subject>Humans</subject><subject>Hybrid Cells</subject><subject>Libraries</subject><subject>Polymerase Chain Reaction</subject><subject>Science and Society</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Tagged Sites</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><sourceid>M0P</sourceid><recordid>eNqN0l1v0zAUBuAIgUYZ_AMmRWhCXJDij9iOL7sKukmFXnRwa506JyVVPjo7keDf46jRxlDFGl9E8nls-dhvFF1QMqWUyU_elthYnDJFpoKl6ZTqVDyLJpRokWhG-PNoQgiXSUaUeBm98n5HSKhpfhadZYJzkslJdDlr4vXtOrkCj3n8FfZxW8TdT4yv-xqaeIFNW-Pr6EUBlcc34_88-v7l8-38OlmuFjfz2TKxGVddkrM0zzYgrZUpyIznTCghZC4gnE8XYpNJK0ACSIak4DLfcEkl46lQCqwCfh69P-y7d-1dj74zdektVhU02PbeKKVCM4o9CbkUVJCUPgmpIoQRmQb47h-4a3vXhG4No1xIHTp8QFuo0JRN0XYO7LCjmVGltdRcBvTxCNpigw6qtsGiDNN_8-QIDyPHurTH_IdHPpAOf3Vb6L03N-tvJ9PVj5Pp1eJUmi2W_7mKkdq2qnCLJmRnvnrExYFb13rvsDB7V9bgfhtKzJB5M2behMybIfNmyHxYdzG-Xb-pMb9fNYY81C_HOngLVeGgsaW_Z0zzjLOBvT2wne9a91DOwkcV_wPy8wpc</recordid><startdate>19951222</startdate><enddate>19951222</enddate><creator>Hudson, Thomas J.</creator><creator>Stein, Lincoln D.</creator><creator>Gerety, Sebastian S.</creator><creator>Ma, Junli</creator><creator>Castle, Andrew B.</creator><creator>Silva, James</creator><creator>Slonim, Donna K.</creator><creator>Baptista, Rafael</creator><creator>Kruglyak, Leonid</creator><creator>Xu, Shu-Hua</creator><creator>Hu, Xintong</creator><creator>Angela M. 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E. Colbert ; Rosenberg, Carl ; Reeve-Daly, Mary Pat ; Rozen, Steve ; Hui, Lester ; Wu, Xiaoyun ; Vestergaard, Christina ; Wilson, Kimberly M. ; Bae, Jane S. ; Maitra, Shanak ; Ganiatsas, Soula ; Evans, Cheryl A. ; DeAngelis, Margaret M. ; Ingalls, Kimberly A. ; Nahf, Robert W. ; Horton, Lloyd T. ; Anderson, Michele Oskin ; Collymore, Alville J. ; Ye, Wenjuan ; Kouyoumjian, Vardouhie ; Zemsteva, Irena S. ; Tam, James ; Devine, Richard ; Courtney, Dorothy F. ; Renaud, Michelle Turner ; Nguyen, Huy ; O'Connor, Tara J. ; Fizames, Cécile ; Fauré, Sabine ; Gyapay, Gabor ; Dib, Colette ; Morissette, Jean ; Orlin, James B. ; Birren, Bruce W. ; Goodman, Nathan ; Weissenbach, Jean ; Hawkins, Trevor L. ; Foote, Simon ; Page, David C. ; Lander, Eric S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c837t-d24d8ba6cc64a683d257556d5a5249f5b86c5a6aa62e0f36db3616234577ac7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Chromosomes, Artificial, Yeast</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Databases, Factual</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genetic loci</topic><topic>Genetic mapping</topic><topic>Genetic Markers</topic><topic>Genetic screening</topic><topic>Genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Human</topic><topic>Human genetics</topic><topic>Human genome</topic><topic>Human Genome Project</topic><topic>Humans</topic><topic>Hybrid Cells</topic><topic>Libraries</topic><topic>Polymerase Chain Reaction</topic><topic>Science and Society</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Tagged Sites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hudson, Thomas J.</creatorcontrib><creatorcontrib>Stein, Lincoln D.</creatorcontrib><creatorcontrib>Gerety, Sebastian S.</creatorcontrib><creatorcontrib>Ma, Junli</creatorcontrib><creatorcontrib>Castle, Andrew B.</creatorcontrib><creatorcontrib>Silva, James</creatorcontrib><creatorcontrib>Slonim, Donna K.</creatorcontrib><creatorcontrib>Baptista, Rafael</creatorcontrib><creatorcontrib>Kruglyak, Leonid</creatorcontrib><creatorcontrib>Xu, Shu-Hua</creatorcontrib><creatorcontrib>Hu, Xintong</creatorcontrib><creatorcontrib>Angela M. 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Colbert</creatorcontrib><creatorcontrib>Rosenberg, Carl</creatorcontrib><creatorcontrib>Reeve-Daly, Mary Pat</creatorcontrib><creatorcontrib>Rozen, Steve</creatorcontrib><creatorcontrib>Hui, Lester</creatorcontrib><creatorcontrib>Wu, Xiaoyun</creatorcontrib><creatorcontrib>Vestergaard, Christina</creatorcontrib><creatorcontrib>Wilson, Kimberly M.</creatorcontrib><creatorcontrib>Bae, Jane S.</creatorcontrib><creatorcontrib>Maitra, Shanak</creatorcontrib><creatorcontrib>Ganiatsas, Soula</creatorcontrib><creatorcontrib>Evans, Cheryl A.</creatorcontrib><creatorcontrib>DeAngelis, Margaret M.</creatorcontrib><creatorcontrib>Ingalls, Kimberly A.</creatorcontrib><creatorcontrib>Nahf, Robert W.</creatorcontrib><creatorcontrib>Horton, Lloyd T.</creatorcontrib><creatorcontrib>Anderson, Michele Oskin</creatorcontrib><creatorcontrib>Collymore, Alville J.</creatorcontrib><creatorcontrib>Ye, Wenjuan</creatorcontrib><creatorcontrib>Kouyoumjian, Vardouhie</creatorcontrib><creatorcontrib>Zemsteva, Irena S.</creatorcontrib><creatorcontrib>Tam, James</creatorcontrib><creatorcontrib>Devine, Richard</creatorcontrib><creatorcontrib>Courtney, Dorothy F.</creatorcontrib><creatorcontrib>Renaud, Michelle Turner</creatorcontrib><creatorcontrib>Nguyen, Huy</creatorcontrib><creatorcontrib>O'Connor, Tara J.</creatorcontrib><creatorcontrib>Fizames, Cécile</creatorcontrib><creatorcontrib>Fauré, Sabine</creatorcontrib><creatorcontrib>Gyapay, Gabor</creatorcontrib><creatorcontrib>Dib, Colette</creatorcontrib><creatorcontrib>Morissette, Jean</creatorcontrib><creatorcontrib>Orlin, James B.</creatorcontrib><creatorcontrib>Birren, Bruce W.</creatorcontrib><creatorcontrib>Goodman, Nathan</creatorcontrib><creatorcontrib>Weissenbach, Jean</creatorcontrib><creatorcontrib>Hawkins, Trevor L.</creatorcontrib><creatorcontrib>Foote, Simon</creatorcontrib><creatorcontrib>Page, David C.</creatorcontrib><creatorcontrib>Lander, Eric S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Biography In Context</collection><collection>Opposing Viewpoints In Context</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; 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E. Colbert</au><au>Rosenberg, Carl</au><au>Reeve-Daly, Mary Pat</au><au>Rozen, Steve</au><au>Hui, Lester</au><au>Wu, Xiaoyun</au><au>Vestergaard, Christina</au><au>Wilson, Kimberly M.</au><au>Bae, Jane S.</au><au>Maitra, Shanak</au><au>Ganiatsas, Soula</au><au>Evans, Cheryl A.</au><au>DeAngelis, Margaret M.</au><au>Ingalls, Kimberly A.</au><au>Nahf, Robert W.</au><au>Horton, Lloyd T.</au><au>Anderson, Michele Oskin</au><au>Collymore, Alville J.</au><au>Ye, Wenjuan</au><au>Kouyoumjian, Vardouhie</au><au>Zemsteva, Irena S.</au><au>Tam, James</au><au>Devine, Richard</au><au>Courtney, Dorothy F.</au><au>Renaud, Michelle Turner</au><au>Nguyen, Huy</au><au>O'Connor, Tara J.</au><au>Fizames, Cécile</au><au>Fauré, Sabine</au><au>Gyapay, Gabor</au><au>Dib, Colette</au><au>Morissette, Jean</au><au>Orlin, James B.</au><au>Birren, Bruce W.</au><au>Goodman, Nathan</au><au>Weissenbach, Jean</au><au>Hawkins, Trevor L.</au><au>Foote, Simon</au><au>Page, David C.</au><au>Lander, Eric S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An STS-Based Map of the Human Genome</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1995-12-22</date><risdate>1995</risdate><volume>270</volume><issue>5244</issue><spage>1945</spage><epage>1954</epage><pages>1945-1954</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases. The project involved assembly of a radiation hybrid map of the human genome containing 6193 loci and incorporated a genetic linkage map of the human genome containing 5264 loci. This information was combined with the results of STS-content screening of 10,850 loci against a yeast artificial chromosome library to produce an integrated map, anchored by the radiation hybrid and genetic maps. The map provides radiation hybrid coverage of 99 percent and physical coverage of 94 percent of the human genome. The map also represents an early step in an international project to generate a transcript map of the human genome, with more than 3235 expressed sequences localized. The STSs in the map provide a scaffold for initiating large-scale sequencing of the human genome.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8533086</pmid><doi>10.1126/science.270.5244.1945</doi><tpages>10</tpages></addata></record>
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identifier ISSN: 0036-8075
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source American Association for the Advancement of Science; Social Science Premium Collection; JSTOR; Education Collection
subjects Animals
Biological and medical sciences
Cell Line
Chromosome Mapping
Chromosomes
Chromosomes, Artificial, Yeast
Classical genetics, quantitative genetics, hybrids
Databases, Factual
Fundamental and applied biological sciences. Psychology
Gene Expression
Genetic loci
Genetic mapping
Genetic Markers
Genetic screening
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human
Genomes
Genomics
Human
Human genetics
Human genome
Human Genome Project
Humans
Hybrid Cells
Libraries
Polymerase Chain Reaction
Science and Society
Sequence Analysis, DNA
Sequence Tagged Sites
title An STS-Based Map of the Human Genome
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