Neurally mediated syncope and serotonin reuptake inhibitors

Serotonin (5-hydroxytryptamine or 5HT) is a neurotransmitter which appears to play a prominent role in central regulation of heart rate and blood pressure. Recent evidence suggests that the activation of cerebral serotonin receptors results in a depressor effect principally through sympatho-inhibiti...

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Bibliographic Details
Published in:Clinical autonomic research 1995-10, Vol.5 (5), p.251-255
Main Authors: Samoil, D, Grubb, B P
Format: Article
Language:English
Subjects:
Animals
Humans
Hypotension - drug therapy
Hypotension - physiopathology
Serotonin Uptake Inhibitors - therapeutic use
Syncope - drug therapy
Syncope - physiopathology
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Summary:Serotonin (5-hydroxytryptamine or 5HT) is a neurotransmitter which appears to play a prominent role in central regulation of heart rate and blood pressure. Recent evidence suggests that the activation of cerebral serotonin receptors results in a depressor effect principally through sympatho-inhibition. Several common clinical disorders resulting in hypotension leading to syncope are neurally mediated syncope, carotid sinus hypersensitivity and orthostatic hypotension, each of which may involve a serotonergic component. This brief review provides a summary of serotonergic blood pressure regulation, as well as the initial experience with the clinical effects of the serotonin reuptake inhibitors in the therapy of the aforementioned disorders.
ISSN:0959-9851
1619-1560
DOI:10.1007/bf01818888