Poly(ADP-ribose) catabolism in mammalian cells

Poly(ADP-ribose) catabolism is a complex situation involving many proteins and DNA. We have developed an in vitro turnover system where poly(ADP-ribose) metabolism is monitored in presence of different relative amounts of two principal enzymes poly(ADP-ribose) transferase and poly(ADP-ribose) glycoh...

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Published in:Molecular and cellular biochemistry 1994-09, Vol.138 (1-2), p.45-52
Main Authors: Lagueux, J, Shah, G M, Ménard, L, Thomassin, H, Duchaine, C, Hengartner, C, Poirier, G G
Format: Article
Language:English
Subjects:
DNA Polymerase II - metabolism
DNA Repair
Peptide Fragments - metabolism
Poly(ADP-ribose) Polymerases - metabolism
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description Poly(ADP-ribose) catabolism is a complex situation involving many proteins and DNA. We have developed an in vitro turnover system where poly(ADP-ribose) metabolism is monitored in presence of different relative amounts of two principal enzymes poly(ADP-ribose) transferase and poly(ADP-ribose) glycohydrolase along with other proteins and DNA. Our current results reviewed here show that the quality of polymer, i.e. chain length and complexity, as well as preference for the nuclear substrate varies depending upon the availability of poly(ADP-ribose) glycohydrolase. These results are interpreted in the light of the recent data implicating poly(ADP-ribose) metabolism in DNA-repair.
doi_str_mv 10.1007/BF00928442
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subjects DNA Polymerase II - metabolism
DNA Repair
Peptide Fragments - metabolism
Poly(ADP-ribose) Polymerases - metabolism
title Poly(ADP-ribose) catabolism in mammalian cells
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