Glomerular epithelial foot processes and filtration slits in IDDM patients

Diabetic nephropathy is associated with functional changes in the glomerular filtration barrier but the structural counterpart remains unknown. Width of glomerular epithelial cell foot processes and of filtration slits were determined by morphometric methods in 11 non-diabetic kidney donors and in 2...

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Bibliographic Details
Published in:Diabetologia 1995-10, Vol.38 (10), p.1197-1204
Main Authors: BJØRN, S. F, BANGSTAD, H.-J, HANSSEN, K. F, NYBERG, G, WALKER, J. D, VIBERTI, G. C, ØSTERBY, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Albuminuria
Analysis of Variance
Associated diseases and complications
Basement Membrane - pathology
Basement Membrane - physiopathology
Basement Membrane - ultrastructure
Biological and medical sciences
Biopsy
Diabetes Mellitus, Type 1 - pathology
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Diabetic Nephropathies - pathology
Diabetic Nephropathies - physiopathology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epithelium - pathology
Epithelium - physiology
Epithelium - ultrastructure
Glomerular Filtration Rate
Humans
Kidney Glomerulus - pathology
Kidney Glomerulus - physiopathology
Kidney Glomerulus - ultrastructure
Medical sciences
Microscopy, Electron
Middle Aged
Reference Values
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Summary:Diabetic nephropathy is associated with functional changes in the glomerular filtration barrier but the structural counterpart remains unknown. Width of glomerular epithelial cell foot processes and of filtration slits were determined by morphometric methods in 11 non-diabetic kidney donors and in 28 diabetic patients with albumin excretion rates ranging from normal to proteinuria. Foot process width was estimated from the ratio of tuft surface density to length density of slits. At high magnification independently sampled, perpendicularly cut slits were classified. Foot process width on peripheral basement membrane was increased in microalbuminuric compared to normoalbuminuric diabetic patients (p
ISSN:0012-186X
1432-0428
DOI:10.1007/bf00422369