Bassiatin, a New Platelet Aggregation Inhibitor Produced by Beauveria bassiana K-717

A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydro...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1995/12/25, Vol.48(12), pp.1407-1413
Main Authors: KAGAMIZONO, TERUMI, NISHINO, EMIKO, MATSUMOTO, KEITA, KAWASHIMA, AKIRA, KISHIMOTO, MARI, SAKAI, NORIYOSHI, HE, BI-MEI, CHEN, ZENG-XIANG, ADACHI, TAKASHI, MORIMOTO, SHIGEO, HANADA, KAZUNORI
Format: Article
Language:English
Subjects:
Animals
Beauveria bassiana
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Crystallography, X-Ray
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Microscopy, Electron, Scanning
Mitosporic Fungi - metabolism
Mitosporic Fungi - ultrastructure
Molecular Structure
Morpholines - chemistry
Morpholines - pharmacology
Pharmacology. Drug treatments
Platelet Aggregation Inhibitors - chemistry
Platelet Aggregation Inhibitors - pharmacology
Rabbits
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2, 5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassiatin inhibited ADP-induced aggregation of rabbit platelets with the IC50 being 1.9×10-4M.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.1407